The Rest of the Story

Jan 10, 2013 21:06

I mentioned acetylcholine (ACh) is the star of one of my favorite neuroscience stories. So here it is ( Read more... )

science, story

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unseelie January 11 2013, 02:29:46 UTC
volta January 11 2013, 09:36:45 UTC
I love it, and not just because I have written more-or-less the text from http://i.imgur.com/qrpXN.jpg on multiple occasions in my various careers.

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volta January 11 2013, 09:43:42 UTC
Now you have me wondering if one of my (many) sleep problems is this acetylcholine/acetylcholinesterase interaction. I guess I have some reading to do before my visit with the sleep docs next week.

Not that I have any sleep problems, mind you. Not having slept since last Friday is not a problem, right? My friend the purple orangutan assures me that is completely normal. On the other hand, he also suggests I should go for a run right now, so clearly he is not right in the head.

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benndragon January 11 2013, 12:09:19 UTC
I'm guessing not, since there would be far worse problems if you had defective ACh/AChesterase than not being able to sleep (not to underestimate insomnia, but basic heart functionality is rather high on the survival list). Even if it was a more localized phenomenon, you'd be perfectly capable of stages 1-4 sleep, just not REM (and you enter REM last in a normal sleep cycle, although when you're sleep-deprived you make it up first).

But you know what is specifically a REM-stage sleep suppressant? Alcohol, even though it's also a soporific. Which possibly explains some of its use as self-medication. . .

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