Some news just in on JAMES:
http://www.comicbookresources.com/news/newsitem.cgi?id=9864 At this point, fans were able to ask their own questions to the panelists as one fan asked if any voice actors from "JLU" animated series will carry over to the movies. The answer was a firm ‘No,’ but they went further by revealing some of the new voices of the "Superman: Doomsday" movie. Adam Baldwin will be the voice of Superman, Ann Heche will provide the voice for Lois Lane, and James Marsters will voice Lex Luthor. Fans may remember that Marsters voiced Brainiac in "Smallville" quite recently.
and this..
http://dvd.ign.com/articles/770/770135p1.html The cast for the feature cartoon is taking a bit of a different twist. Though sporting Timm's typical clean, block-style designs, the voices will be different. Gone is the talent behind Justice League Unlimited. Tim stated that he really wanted to differentiate these projects from the past serialized shows. To that end, he revealed three of the main characters in the story and the talent attached to them. Adam Baldwin will be portraying the Man of Steel himself, Clark Kent. Anne Heche will be taking on the role of Lois Lane. James Marsters, known as Spike to many, will be doing a new take on Lex Luthor. Timm specifically noted that the writing team had reconstructed and analyzed Luthor to find a suitable role for this project.
and also, a really Spike positive review on the comic:
http://www.thestar.com/artsentertainment/article/187953