Already searched : “medieval illness/disease”, “medieval epidemics”, “epidemics”, etc + the various diseases that presented themselves during those searches but without much success for my specific set of requirements. So I turn to you lovely people for help ...
Setting : Medieval (late 12th century) - Middle east (present day Lebanon) in a
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Medieval descriptions of such things in western chronicles can be rather unspecific, in that period; they tend to just mention pestilence or the like.
Other internet searches that could possibly throw something up something useful: illness and the Second and Third Crusades (approximately contemporary and I seem to remember there was illness among the crusaders), early Arabic medicine.
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https://en.wikipedia.org/wiki/Category:Ailments_of_unknown_cause
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During its first recorded European outbreak (Naples, 1490s) it was contagious, swift-acting, painful, disfiguring, and 100% lethal.
By 1750, it was remained contagious (still is today), but symptoms might take weeks - even months - to appear and a healthy younger person might live years (or even a decade).
How much of this is due to weakening of the disease and how much to Darwinian pruning of the less-resistant population is left as an exercise for the reader.
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Am Syrian and Lebanese (and a medic).
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You also appear to need an animal vector, as in malaria, bubonic plague and avian flu. The problem here is that they tend to spread geographically quickly and easily; on several occasions bubonic plague spread across the whole of Europe within a few years as the vectors travelled or were taken, and malaria was found in marshy areas even in Britain until quite recently. If avian flu gets into the wild bird population it will be impossible to control.
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