She does like cocaine, apparently.

Nov 14, 2006 08:18

Hu et al (2004) state that women are at greater risk for cocaine addiction. Hu et al used a rat model to examine gender differences in cocaine sensitization and addiction. They found that there were both hormonal and structural components to the female propensity towards cocaine self-administration in rats. Lukas et al (1994) studied cocaine effects in human subjects, and found that (given a weight-dependent dose) men had higher plasma cocaine levels and reported more intense subjective effects. However, women and men had similar heart-rate response. Plasma levels in women were distinctly affected by menstrual cycle. Lynch et al's 2002 review suggests that women are more vulnerable than men to several phases of the drug-abuse cycle: acquisition, maintenance, escalation, and relapse.

Once again, we trip over a subject with which I have little to no personal experience. I'm a very competitive person, and I always feel the need to "keep up" with the people that I'm around -- I've made myself ill keeping up on coffee, on cigarettes, and on alcohol. That being the case, I've kept the less legal recreationals largely out of my life, because I didn't trust myself to know when to stop. The studies above suggest that although women aren't feeling as great a subjective reward for their drug use, they're more driven to continue, which makes me realize exactly how little I know about the process of addiction.

drugs, animal studies, sex differences, rat studies, women, neuroscience, cocaine, addiction

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