1) Whenever we see those “X-turned-into-sparkling-via-gun/explosion/etc” fics, it always ends up with the Autobots taking care of the sparklings, whether they’re Autobots or Decepticons. Why can’t the Decepticons take care of them for once? And actually be good at it? Tell me you can’t see Soundwave collecting sparklings like Pokemon, or Megatron (privately) spoiling them rotten?
2) What if, instead of joining the Decepticons OR the Autobots, Starscream went Neutral during the war? Unknown, until something about him attracts the interest of BOTH groups. (What this “something” is, I don’t know. That’s up to the writer.)
3) Soundwave and Blaster are twins.
4) There actually were NO other Seekers aside from Starscream in the beginning, which lead to some experimentation. In other words, Starscream as the creator of Thundercracker, Skywarp, and the Coneheads, and everyone else was just copied/mass-produced from there. (By "creator", I mean actually putting effort into them. Not mass-cloning like TF:A Starscream.)
5) Movieverse: Megatron as Optimus’ creator. Because c'mon, did you see how bad a beatdown Optimus received during Mission City? There's gotta be another reason he's still alive. And there's already plenty of the "secretly-still-in-love" version.