Bruce Greenwood as Batman.
John DiMaggio as the Joker.
Jensen Ackles as the Red Hood.
Jason Isaacs as Ra's Al Ghul.
Neil Patrick Harris as Nightwing.
Not the best casting, but they did cast some A-list names. I'm not really sure about NPH since Dick doesn't sound like him in my head, but you know, to each their own. I went to youtube and tried to listen (not watch) a couple of video with him and I still think he's not my Dick. He's not a bad choice, but his not my first choice.
Isaac can be creepy as hell as most HP fans know. Forget the fans, if you've watched one HP movie with him you know that the man is the right choice for Ra's. He has something classy yet scarry on him. If he orders you to give him your body you'll probably do what he asking :P
I'll have a hard time not to think about Bender everytime Joker will be on the movie. The weird part is that I never thought of Bender, not once, while playing Gears of War.
Jensen as Jayson Todd. It could be worst. But he's not a bad choice. His voice is deep and smoky and has a badass tone so I think he's going to be a pretty good Jayson. I'm just worried that Dick is going to sound like a kid playing man.
Anyway, I think that DC/WB realized that anime are not for kids anymore and they try their best to sell their product(s). Marvel already knew that of course (Hugh Jackman anyone?). Of course I'll have to wait and see. I can't judge something I haven't seen, but it looks promising.