Микрохимеризм (Y хромосома в женском мозге)
Оригинал взят у majasuave в Микрохимеризм (Y хромосома в женском мозге)
Микрохимеризм - явление, характеризующееся наличием в многоклеточном организме (плацентарные млекопитающие) небольшого количества клеток, которые происходят и самостоятельно передаются в обход полового размножения от другого родственного многоклеточного организма и, следовательно, генетически отличны от клеток хозяина-носителя. Это явление может быть связано с определенными типами аутоиммунных заболеваний, однако механизмы, ответственные за эту связь, пока не ясны.
(c)http://ru.wikipedia.org/wiki/Микрохимеризм
http://en.wikipedia.org/wiki/Microchimerism
http://www.microchimerism.org
Naturally acquired microchimerism http://www.ncbi.nlm.nih.gov/pubmed/19924635
Одна из причин - обмен клетками при беременности
Мужской микрохимеризм в женском мозге: 37 из 59 исследованных женщин имели Y-хромосому в головном мозге
Male Microchimerism in the Human Female Brain
William F. N. Chan1*¤, Ce ́cile Gurnot1, Thomas J. Montine2, Joshua A. Sonnen2, Katherine A. Guthrie1, J. Lee Nelson1,3
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America,
2 Department of Pathology, University of Washington, Seattle, Washington, United States of America,
3 Division of Rheumatology, University of Washington, Seattle, Washington, United States of America
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0045592&representation=PDF
In humans, naturally acquired microchimerism has been observed in many tissues and organs. Fetal microchimerism, however, has not been investigated in the human brain. Microchimerism of fetal as well as maternal origin has recently been reported in the mouse brain. In this study, we quantified male DNA in the human female brain as a marker for microchimerism of fetal origin (i.e. acquisition of male DNA by a woman while bearing a male fetus).
Targeting the Y- chromosome-specific DYS14 gene, we performed real-time quantitative PCR in autopsied brain from women without clinical or pathologic evidence of neurologic disease (n = 26), or women who had Alzheimer’s disease (n = 33). We report that 63% of the females (37 of 59) tested harbored male microchimerism in the brain. Male microchimerism was present in multiple brain regions. Results also suggested lower prevalence (p = 0.03) and concentration (p = 0.06) of male microchimerism in the brains of women with Alzheimer’s disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain.
Микрохимеризм - явление, характеризующееся наличием в многоклеточном организме (плацентарные млекопитающие) небольшого количества клеток, которые происходят и самостоятельно передаются в обход полового размножения от другого родственного многоклеточного организма и, следовательно, генетически отличны от клеток хозяина-носителя. Это явление может быть связано с определенными типами аутоиммунных заболеваний, однако механизмы, ответственные за эту связь, пока не ясны.
(c)http://ru.wikipedia.org/wiki/Микрохимеризм
http://en.wikipedia.org/wiki/Microchimerism
http://www.microchimerism.org
Naturally acquired microchimerism http://www.ncbi.nlm.nih.gov/pubmed/19924635
Одна из причин - обмен клетками при беременности
Мужской микрохимеризм в женском мозге: 37 из 59 исследованных женщин имели Y-хромосому в головном мозге
Male Microchimerism in the Human Female Brain
William F. N. Chan1*¤, Ce ́cile Gurnot1, Thomas J. Montine2, Joshua A. Sonnen2, Katherine A. Guthrie1, J. Lee Nelson1,3
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America,
2 Department of Pathology, University of Washington, Seattle, Washington, United States of America,
3 Division of Rheumatology, University of Washington, Seattle, Washington, United States of America
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0045592&representation=PDF
In humans, naturally acquired microchimerism has been observed in many tissues and organs. Fetal microchimerism, however, has not been investigated in the human brain. Microchimerism of fetal as well as maternal origin has recently been reported in the mouse brain. In this study, we quantified male DNA in the human female brain as a marker for microchimerism of fetal origin (i.e. acquisition of male DNA by a woman while bearing a male fetus).
Targeting the Y- chromosome-specific DYS14 gene, we performed real-time quantitative PCR in autopsied brain from women without clinical or pathologic evidence of neurologic disease (n = 26), or women who had Alzheimer’s disease (n = 33). We report that 63% of the females (37 of 59) tested harbored male microchimerism in the brain. Male microchimerism was present in multiple brain regions. Results also suggested lower prevalence (p = 0.03) and concentration (p = 0.06) of male microchimerism in the brains of women with Alzheimer’s disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain.