New Theory Emerges to Explain Mental Disorders
I know, more news instead of an update :} I don't know that you want an update based on the knowledge that I'm operating with about 4.5 hours of sleep and a disastrous cough, or that LG was up last night with the same coughing affliction and each time I tried to put him down, Bubs would cough and promptly wake LG up again :} So this will have to suffice. Amazingly, I have managed to get quite a lot done today in spite of the sleep deprivation -- I take that to mean the thyroid meds are doing their thing.
This topic touches both friends and immediate family...
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Full article at the NYT -- In a Novel Theory of Mental Disorders, Parents’ Genes Are in Competition
Two scientists, drawing on their own powers of observation and a creative reading of recent genetic findings, have published a sweeping theory of brain development that would change the way mental disorders like autism and schizophrenia are understood.
The theory emerged in part from thinking about events other than mutations that can change gene behavior. And it suggests entirely new avenues of research, which, even if they prove the theory to be flawed, are likely to provide new insights into the biology of mental disease.
Their idea is, in broad outline, straightforward. Dr. Crespi and Dr. Badcock propose that an evolutionary tug of war between genes from the father’s sperm and the mother’s egg can, in effect, tip brain development in one of two ways. A strong bias toward the father pushes a developing brain along the autistic spectrum, toward a fascination with objects, patterns, mechanical systems, at the expense of social development. A bias toward the mother moves the growing brain along what the researchers call the psychotic spectrum, toward hypersensitivity to mood, their own and others’. This, according to the theory, increases a child’s risk of developing schizophrenia later on, as well as mood problems like bipolar disorder and depression.
In short: autism and schizophrenia represent opposite ends of a spectrum that includes most, if not all, psychiatric and developmental brain disorders. The theory has no use for psychiatry’s many separate categories for disorders, and it would give genetic findings an entirely new dimension.
The theory also does not fit all of the various quirks of autism and schizophrenia on flip sides of the same behavioral coin. The father of biological psychiatry, Emil Kraepelin, in the late 1800s made a distinction between mood problems, like depression and bipolar disorder, and the thought distortions of schizophrenia - a distinction that, to most psychiatrists, still holds up Many people with schizophrenia, moreover, show little emotion; they would seem to be off the psychosis spectrum altogether, as the new theory describes it.
But experts familiar with their theory say that the two scientists have, at minimum, infused the field with a shot of needed imagination and demonstrated the power of thinking outside the gene. For just as a gene can carry a mark from its parent of origin, so it can be imprinted by that parent’s own experience.
This topic touches both friends and immediate family...
===
Full article at the NYT -- In a Novel Theory of Mental Disorders, Parents’ Genes Are in Competition
Two scientists, drawing on their own powers of observation and a creative reading of recent genetic findings, have published a sweeping theory of brain development that would change the way mental disorders like autism and schizophrenia are understood.
The theory emerged in part from thinking about events other than mutations that can change gene behavior. And it suggests entirely new avenues of research, which, even if they prove the theory to be flawed, are likely to provide new insights into the biology of mental disease.
Their idea is, in broad outline, straightforward. Dr. Crespi and Dr. Badcock propose that an evolutionary tug of war between genes from the father’s sperm and the mother’s egg can, in effect, tip brain development in one of two ways. A strong bias toward the father pushes a developing brain along the autistic spectrum, toward a fascination with objects, patterns, mechanical systems, at the expense of social development. A bias toward the mother moves the growing brain along what the researchers call the psychotic spectrum, toward hypersensitivity to mood, their own and others’. This, according to the theory, increases a child’s risk of developing schizophrenia later on, as well as mood problems like bipolar disorder and depression.
In short: autism and schizophrenia represent opposite ends of a spectrum that includes most, if not all, psychiatric and developmental brain disorders. The theory has no use for psychiatry’s many separate categories for disorders, and it would give genetic findings an entirely new dimension.
The theory also does not fit all of the various quirks of autism and schizophrenia on flip sides of the same behavioral coin. The father of biological psychiatry, Emil Kraepelin, in the late 1800s made a distinction between mood problems, like depression and bipolar disorder, and the thought distortions of schizophrenia - a distinction that, to most psychiatrists, still holds up Many people with schizophrenia, moreover, show little emotion; they would seem to be off the psychosis spectrum altogether, as the new theory describes it.
But experts familiar with their theory say that the two scientists have, at minimum, infused the field with a shot of needed imagination and demonstrated the power of thinking outside the gene. For just as a gene can carry a mark from its parent of origin, so it can be imprinted by that parent’s own experience.