[It's kind of a spoiler?] I'm a little creeped out by the whole thing Sam had with Madison and then in the Terrible Life 'verse him calling her number and getting an animal hospital...and then here comes Amelia.
Mostly not thinking about the premier tomorrow, but, [not really a spoiler but just in case...] I would really like to see Dean giving up on beds and just sleeping sitting up in the corner with a machete or some other weapon in his hand or across his lap.