lisa said my last post was boring...
...so here's my rough draft for my abstract i'm submitting for the undergrad research symposium
Probing Diastereoselectivity of Cyclizations of Chiral Amino Alkenes
Controlling stereoselectivity is important in applications of organic synthesis because stereochemistry can determine the biological effectiveness of a compound, which is crucial in the manufacturing of pharmaceuticals. For example it was discovered that one enantiomer of thalidomide has teratogenic effects. Exploring the factors that influence stereochemistry is of great interest as it reveals the mechanistic controls needed to selectively synthesize a stereoisomer. By synthesizing a chiral amino alkene substrate we can study the effect of chiral directing groups in cyclization reactions such as hydroamination, chloroamination, carboamination, diamination, and alkoxyamination. We can determine the diastereoselectivity through molecular characterizations via spectroscopic methods such as proton nuclear magnetic resonance (H NMR) and high performance liquid chromatography (HPLC) and use the information we gather to optimize diastereoselective conditions of our choice.
thoughts?
Probing Diastereoselectivity of Cyclizations of Chiral Amino Alkenes
Controlling stereoselectivity is important in applications of organic synthesis because stereochemistry can determine the biological effectiveness of a compound, which is crucial in the manufacturing of pharmaceuticals. For example it was discovered that one enantiomer of thalidomide has teratogenic effects. Exploring the factors that influence stereochemistry is of great interest as it reveals the mechanistic controls needed to selectively synthesize a stereoisomer. By synthesizing a chiral amino alkene substrate we can study the effect of chiral directing groups in cyclization reactions such as hydroamination, chloroamination, carboamination, diamination, and alkoxyamination. We can determine the diastereoselectivity through molecular characterizations via spectroscopic methods such as proton nuclear magnetic resonance (H NMR) and high performance liquid chromatography (HPLC) and use the information we gather to optimize diastereoselective conditions of our choice.
thoughts?