So my reaction to that interview is basically the same as everyone else: concern, hesitation, a healthy does of panic and preemptive grief.
My boyfriend's reaction, however, is freaking hilarious.
Boyfriend: Jensen should shut the fuck up.
bree_black : *distracted by her misery* ...what?
Boyfriend: What does he know, anyway?
bree_black : Uh, a fair bit, I'd think.
Boyfriend: He's just an actor! Actors don't matter. He should just shut up and do what the writers tell him.
So...he's pleased. Mind you, he ships Dean/Lisa with a fire-y passion and wants them to live happily ever after behind a white picket fence while Sam roasts painfully in Hell forever. So not a typical SPN viewer.