'Splains a lot.
Mom suddenly informed me, as we were talking about all my medical conditions, about the experimental, now illegal, synthetic hormone she took to keep from mis-carrying me like the three babies before me.
I have done lots of research on DES since that little talk.
Men exposed to DES before birth (in the womb), known as DES sons, are at an increased risk for non-cancerous epididymal cysts and auto-immune disorders.[citation needed] Diethylstilbestrol can also cause feminisation of the male foetus, as DES undergoes metabolic epoxidation, and the epoxide product has affinity towards the estrogen receptors.[citation needed] In some cases there are sons with only one testis or both abdominal. In 2002, a study indicated that maternal usage of DES resulted in a 20-fold increase in prevalence of hypospadias in their sons[23] although a followup study showed the risk, though present, to be much lesser.[24]
Some studies suggest that otherwise-male children exposed to DES before birth may be more likely to be transsexual woman than otherwise-male children who have not been exposed.[25]
In the 1970s, the negative publicity surrounding the discovery of DES's long-term effects resulted in a huge wave of lawsuits in the United States against its manufacturers. These culminated in a landmark 1980 decision of the Supreme Court of California, Sindell v. Abbott Laboratories, in which the court imposed a rebuttable presumption of market share liability upon all DES manufacturers, proportional to their share of the market at the time the drug was consumed by the mother of a particular plaintiff.
Researchers are still following the health of persons exposed to DES to determine whether other health problems occur as they grow older.
I have done lots of research on DES since that little talk.
Men exposed to DES before birth (in the womb), known as DES sons, are at an increased risk for non-cancerous epididymal cysts and auto-immune disorders.[citation needed] Diethylstilbestrol can also cause feminisation of the male foetus, as DES undergoes metabolic epoxidation, and the epoxide product has affinity towards the estrogen receptors.[citation needed] In some cases there are sons with only one testis or both abdominal. In 2002, a study indicated that maternal usage of DES resulted in a 20-fold increase in prevalence of hypospadias in their sons[23] although a followup study showed the risk, though present, to be much lesser.[24]
Some studies suggest that otherwise-male children exposed to DES before birth may be more likely to be transsexual woman than otherwise-male children who have not been exposed.[25]
In the 1970s, the negative publicity surrounding the discovery of DES's long-term effects resulted in a huge wave of lawsuits in the United States against its manufacturers. These culminated in a landmark 1980 decision of the Supreme Court of California, Sindell v. Abbott Laboratories, in which the court imposed a rebuttable presumption of market share liability upon all DES manufacturers, proportional to their share of the market at the time the drug was consumed by the mother of a particular plaintiff.
Researchers are still following the health of persons exposed to DES to determine whether other health problems occur as they grow older.