This Is Beginning to Look Very Interesting!!!
Around dawn on Wednesday, I posted Perhaps My Narcolepsy Solved?
Susan responded this evening with more information and encouragement. I just wrote back to her.
Looks like I shall be ordering a form of B-12 I had never heard of until Susan mentioned it this evening.
HYDROXOCOBALAMIN EXTREME™
#PH167
5000 mcg, 30 tablets $29.49
THE B-12 YOUR BRAIN NEEDS FOR DETOX & SHARPNESS
Sharpen brain function with potent nitric oxide detoxification
Helps remove heavy metals from your system
Slow absorption for maximum benefit
Boost your brain with this potent component of vitamin B-12. Studies have shown that ME/CFS patients present with high levels of nitric oxide and its oxidant product peroxynitrite, which affects brain function and pain sensitivity. Hydroxocobalamin is the most powerful scavenger of nitric oxide. It also helps manufacture the myelin sheath that acts as a protective layer around the brain and helps produce neurotransmitters, which are vital for brain communications.
Until now, the only way to get this level of hydroxocobalamin therapy was through injection. In fact, many ME/CFS physicians have been using such injections as effective therapy for their patients. And because of its effects on the brain, hydroxocobalamin is being used more and more in treatments for autism.
https://www.prohealth.com/shop/product.cfm/product__code/PH167/tab/Description#title
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Alobar,
How interesting! (I've also never had a cigarette...I just thought it was gross and smelly...)
I don't know of an upward dose of methyl-B12, but if you are out looking, you might see if you can find some hydroxycobalamin or aquacobalamine. It detoxes cyanide too, and maybe has less of the downside of methyl-B12 from the article below.
How likely do you think that in the article below on diabetes, that the cobalamin that elevated in the blood was cyanocobalamin?
Please keep us posted as anything changes!
I'm so sorry. Sounds like a troubling development!
Susan
Neuroreport. 1997 Dec 22;8(18):3861-5.
Central administration of vitamin B12 aggravates cataplexy in canine narcolepsy.
Honda K, Riehl J, Inoué S, Mignot E, Nishino S.
Sleep Disorders and Research Center, Stanford University, Palo Alto, CA 94304, USA.
Abstract
Experimental evidence in canine narcolepsy suggests that central cholinergic systems are critically involved in the regulation of cataplexy, an abnormal manifestation of REM sleep atonia. In the current study, we found that intracerebroventricular perfusion of methyl-B12, (10(-5)-10(-2) M), significantly aggravated cataplexy and enhanced REM sleep in narcoleptic dogs. Choline, a direct precursor of acetylcholine, was also found to aggravate cataplexy, while cyano-B12, a vitamin B12 analog without methyl donating abilities, had no effect on cataplexy. Since both methyl-B12 and choline are reported to enhance acetylcholine synthesis, enhancement of the biosynthesis of acetylcholine may be involved in the effects observed in canine narcolepsy. Our results suggest that central administration of methyl-B12 has the potential to modulate both normal and pathological REM sleep.
PMID: 9462456
Diabetes Care. 2011 Mar 18. [Epub ahead of print]
Diabetes as a Cause of Clinically Significant Functional Cobalamin Deficiency.
Solomon LR.
Section of Palliative Care, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Abstract
OBJECTIVE Functional cobalamin (Cbl) deficiency (i.e., high methylmalonic acid [MMA] values despite normal serum Cbl levels) is common in the elderly and associated with neuropathy and anemia. Because diabetes is also common in the elderly and diabetic neuropathy resembles that of Cbl deficiency, the role of diabetes in functional Cbl deficiency was explored. RESEARCH DESIGN AND METHODS A retrospective review was performed of all ambulatory community-dwelling adults with normal renal function evaluated for Cbl deficiency over a 12-year period in a primary care setting. Functional Cbl deficiency was defined as MMA values >250 nmol/L with Cbl levels >400 pg/mL. RESULTS In nondiabetic subjects, MMA values varied directly with age and inversely with serum Cbl. In diabetic subjects, MMA values also increased with age but did not fall as Cbl levels increased. Thus, when Cbl levels were >400 pg/mL, mean MMA values and the incidence of functional Cbl deficiency were both significantly greater in elderly diabetic subjects (at least 70 years old) than in elderly nondiabetic subjects. Moreover, neuropathy was present in 62% of diabetic subjects with high MMA values and in only 18% of diabetic subjects with normal MMA values. Finally, pharmacologic doses of Cbl improved MMA values and neuropathy in 88 and 86% of evaluable diabetic subjects, respectively. CONCLUSIONS These observations suggest that functional Cbl deficiency is common in elderly diabetic individuals, is associated with neuropathy, and is responsive to Cbl therapy. A role for oxidative stress in the pathogenesis of functional Cbl deficiency is proposed.
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Hi Susan,
On the coconut oil list there is a discussion thread on neuropathy which indicates that 40 mg of Methyl B-12 would be safe (see below). I was not planning to go above 12 mg, twice daily, probably starting with half that.
I located hydroxycobalamin on-line, but no aquacobalamine. Hydroxycobalamin looks interesting, albeit expensive. I shall try it for a month, then go back to high dose methyl-B12.
https://www.prohealth.com/shop/product.cfm/product__code/PH167/tab/Label#title
Yes, I would suspect the difficulty in the study you quote was from Cyano-B12
Yes, troubling, but I find most learning experiences to be troubling, but one the difficulty has been solved, I feel like many what I learned may be of use to others. Being my own lab rat really feeds my Aspie inward scrutiny perseveration. So the quest brings joy, even though it is scary sometimes.
> http://www.lef.org/protocols/neurological/neuropathy_01.htm
>
>
> The following supplements have been shown to reduce the pain associated with neuropathy:
>
> * Fat-soluble vitamin B1 (benfotiamine)-150 milligrams (mg) one to three times daily
> * Acetyl-L-carnitine-2000 mg daily
> * R-lipoic acid-300 to 450 mg daily (or alpha-lipoic acid: 600 to 1000 mg daily)
> * NAC-600 mg daily
> * Curcumin-800 to 1600 mg daily
> * Gamma linolenic acid (GLA)-900 to 2700 mg daily
> * EPA/DHA-4000 mg daily, providing at least 1400 mg EPA and 1000 mg DHA
> * Vitamin B6-100 mg daily
> * Vitamin B12-1000 micrograms (mcg) of the methylcobalamin form, taken one to four times daily (up to 40 mg daily methylcobalamin may be used in extreme cases)
> * Vitamin C-about 2500 mg daily
> * Vitamin E-400 international units (IU) daily (with around 200 mg gamma tocopherol)
>
> Read the full article at the above link.
Alobar