3 млн

[chuka_lis]

Число смертей от коронавируса САРС2 в мире перевалило за 3 млн.

Coronavirus Cases:
140,547,010
Deaths:
3,012,649
Ранее самым смертоносным (по количеству  случаев в мире) инфекционным заболеванием был туберкулез. Не такой "молниеносный", как ковид.
За год от ковида умерло 2.5 раза больше, чем оценочная  смертность от туберкулеза (согласно оценкам ВОЗ, в

Comments

[strannik1]

С а не ОТ

https://www.biorxiv.org/content/10.1101/2021.04.20.439992v1

[wistar_19]

Han L., Li C., Sun B., Xie Y., Guan Y., Ma Z., Chen L.
Protective effects of celastrol
on diabetic liver injury
via TLR4/myd88/NF-κB signaling pathway

Re: https://www.biorxiv.org/content/10.1101/2021.04.20.439992v1

[chuka_lis]

Here we identified celastrol, a pentacyclic triterpene isolated from Tripterygium wilfordii Hook F - a plant used in traditional Chinese medicine - as one of the best compounds out of 39 repurposed drug candidates. Celastrol reverted gene expression signature from SARS-CoV-2-infected cells; bound with high-affinity energy to viral molecular targets such as main protease (Mpro) and receptor-biding domain (RBD); inhibited SARS-CoV-2 replication in monkey (Vero and Vero-ACE2) and human (Caco-2 and Calu-3) cell lines; and decreased interleukin-6 (IL-6) secretion in SARS-CoV-2-infected human cell lines. Interestingly, celastrol acted in a concentration-dependent manner, with undetectable signs of cytotoxicity. Therefore, celastrol is a promising lead drug candidate to treat Covid-19 due to its ability to suppress SARS-CoV-2 replication and IL-6 production in infected cells, two critical events in the pathophysiology of this disease.
- интересные данные, спасибо.

Re: https://www.biorxiv.org/content/10.1101/2021.04.20.439992v1

[chuka_lis]

хотя, ввиду токсичности вещества и растения, врядли в этом направлении далеко продвинутся.
http://lifebio.wiki/%d1%82%d1%80%d0%b8%d0%bf%d1%82%d0%b5%d1%80%d0%b8%d0%b3%d0%b8%d1%83%d0%bc_%d0%b2%d0%b8%d0%bb%d1%8c%d1%84%d0%be%d1%80%d0%b4%d0%b0