Two HSP90 ligands I found today:
NP4 and
NP5What's wrong with them? Well, "normal" sizes for rings in organic chemistry are 3, 5, 6 and 7 carbon atoms. 3 carbons form a triangle, which is thermodynamically unstable because of the strain in the bonds (carbon atoms with all single bonds usually have bond angles around 109.5 degrees, and in a triangle
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