WARNING!
DO NOT DRINK!
Isopropanol has 2-3 times the potency of ethanol and causes hypotension and CNS and respiratory depression more readily than ethanol. Peak levels occur approximately 30 minutes after ingestion because of rapid GI absorption, which is delayed in the presence of food. Isopropanol is a CNS and cardiac depressant with about twice the potency of ethanol. Serum levels more than 400 mg/dL are potentially fatal. Approximately 20-50% of isopropanol is excreted unchanged by the kidney, while 50-80% is converted in the liver to acetone, which is a CNS depressant in its own right. Acetone is excreted primarily by the kidneys, with some excretion through the lungs. The elimination half-life of isopropanol is 4-6 hours; that of acetone is 16-20 hours. The prolonged CNS depression seen with isopropanol ingestion is partially related to acetone's CNS depressant effects.