(no subject)
Amanda and Casey came over this morning to pick me up...brought me to paris in peril practice. oh my hot weather god...Got home at 4ish, went school shopping. Woo..I saw this black kid in uh, this store, and I accidentally stepped on his shoes. "Oh shit, I stepped on his K-Swiss..I'm going to die.." Came home and downloaded a lot more music, and uh..the end.
One of the easiest ways to make methamphetamine is from amphetamine. Of course, this assumes you have amphetamine in the first place, but let's just pretend you have some and you want to spice it up a bit.The difference between amphetamine and methamphetamine is the addition of a single methyl group (CH3) to the amino group sticking off the middle carbon atom in the chain. Fortunately, substituting amines is really simple. Vaporize your amine (your amphetamine) with a bunch of vaporized chloromethane (CH3Cl, a solvent) and some gaseous pyridine... voila, the amino group takes the methyl from the chloromethane and lets a hydrogen go. The hydrogen joins the liberated chlorine, and the resulting HCl is soaked up by the pyridine. The pyridine is optional. Adding it drives the reaction a bit by pulling the excess HCl out of the equation, butit'snotneessary Assuming you don't have amphetamine lying around, an easy synthesis with a very high yield is to reduce the condensation product of phenylacetone and methylamine. The benefit of this method is that different amines can be used to produce novel N-alkyl amphetamines (ethamphetamine, tert-butylamphetamine, etc)Making it from ephedrine or pseudoephedrine is possible. The only difference between methamphetamine and (pseudo)ephedrine is that damn alpha-hydroxy group. Reacting your ephedrine with thionyl chloride replaes the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an intermediate. Hydrogenating this product is easy: use lithium aluminum hydride, sodium borohydride, or even hydrogen gas with nickel or platinum metal as a catalyst. The product of this step is N-methylamphetamine and HCl. Evaporate off the water and you have methamphetamine hydrochloride.A surprisingly simple synthesis is possible from the amino acid phenylalanine, which is available at health food stores for about $14 for 100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic acid, which is more or less amphetamine with a COOH where the CH3 should be at the end of the chain. Thionyl chloride will replace the OH with a Cl, which falls off and is replaced by H when you give it lithium aluminum hydride, sodium borohydride, or hydrogen gas and nickel/platinum. If you use hydrogen and metal for that step, you'll have to reduce the carbonyl group with one of the hydrides, so best save time + effort and use them and do both reductions at once. When that carbonyl is reduced, you now have amphetamine. Go back up to that first one I mentioned for upgrading amphetamine into methamphetamine.Note that azll of these (and probably anything anyone ever comes up with) will give you a mix of d- and l- isomers. The d- is cool, the l- is shit, remember. If you have time, energy, and equipment, you can separate the two and reprocess the l- into d- by oxidizing it and re-aminating it. Glassware125 ml separatory funnel with 24/40 $ joint1000 ml 3-neck, 24/40, 34/40, 24/40 $ joint round-bottom flaskmercury-sealed stirrer with nitrogen inletPyrex stirring rod50-5000 RPM stirring motorAllin condenser with 34/40 $ jointcalcium chloride drying tube500 ml 2-neck 24/40, 34/40 $ joint round-bottom flask24/40, 24/40 $ joint condenser34/40 to 24/40 $ joint Pyrex adapterrubber stoppers to fit reaction flaskssix feet of small glass tubingtwo feet of rubber tubing for various connectionselectric hotplatelarge ringstandChemicals200 ml 40% methylamine in waterhydrochloric acid for HCl reactiontable salt for HCl reactionone pint of methanol for condenser coolingone tank of commercial nitrogencalcium chloride for drying tube84.3 ml benzyl chloride16.2 g magnesium turnings2 lbs. anhydrous ethersmall amount of crystalline iodine44 g acetaldehyde NOTE: hydrogen chloride gas is produced by treating salt with HCl acid. This is done in a small wash bottle and the gas is bubbled through sulfuric acid before it is bubbled through the methamphetamine solution.setup #1:start with 1000 ml 3-neck round-bottom flaskinto the 3 necks put:24/40 $ joint: 125 ml separatory funnel34/40 $ joint: Allin condenser24/40 $ joint: mercury-sealed stirrer w/nitrogen inletto Allin condenser attach:calcium chloride drying tubeto stirrer attach:Pyrex stirring rod50-5000 RPM stirring motorThe Allin condenser is cooled with water cooled to 0 celsius with ice. Nitrogen is slowly added from a cylinder.setup #2:start with 500 ml 2-neck round-bottom flaskinto the 2 necks put:24/40 $ joint: 24/40-24/40 condenser34/40 $ joint: glass CH3NH2 input tubeinto top of 24/40 condenser put:24/40-34/40 adapterinto top of adapter, put:Allin condenserin "bottom" of 34/40 Allin condenserglass CH3NH2 input tube from 500 ml flaskfrom Allin condenserexit tube (to 1000 ml flask)bottom condenser is cooled with methanol and dry iceusing 1000 ml 3-neck round-bottom flaskstopper middle neckfrom one neck:glass CH3NH2 input tube to:"top" of Allin condenserfrom other neck:glass exit tube from Allin condenserSynthesisSet up reaction flask as in setup #1.The nitrogen is turned on and the system is flushed.Add to the flask 16.2 g magnesium turnings and 66.6 ml anhydrous ether.Next add a small crystal of iodine and 25 ml of a solution of 84.3 ml benzyl chloride dissolved in 333.3 ml anhydrous ether.This is left for 30 min to let the reaction start.The iodine color will disappear when the reaction starts. If it does not start within 30 minutes, the flask is pertially immersed in water heated to 104 Fahrenheit.As soon as the reaction starts, the remainder of the benzyl chloride solution is added during the course of 30 minutes.The stirrer is started as soon as the benzyl chloride is added.The reaction temperature is regulated by keeping the greater part of the reaction flask immersed in ice water.The reaction will continue for about 15 minutes after all the benzyl chloride solution has been added. After this the reaction flask is refluxed for 15 minutes.This is done by simply heating the reaction flask with an electric hot plate so that there is a gentle boiling in the flask.After this has been completed, 44 g acetaldehyde is dropped slowly into the reaction flask. This is done with constant stirring.The temperature rises and is kept there (50 Celsius) for 2 hours.After this is completed, the methylation part of the synthesis is set up as per setup #2.Approximately 200 ml 40% methylamine in water is added to the 500 ml reaction flask. This is slowly heated, and not allowed to rise above 150 Fahrenheit.The bottom condenser is cooled with methanol, which is cooled with dry ice.The aseousmethylamine is bubbled through the 1000 ml flask for 3 hours.An exothermic reaction takes place during this time.This is allowed to cool slowly and then extracted with ether and the extracts allowed to evaporate.The residue is methamphetamine base, which then must be converted to the hydrochloride salt.The methamphetamine is dissolved in 200 ml dry ether and dry hydrogen chloride gas is bubbled through the solution until the precipitate is no longer formed.The precipitate is removed by suction filtration and recrystallized from dry ether to obtain the pure product. Congratulations, you now have speed, fucker.