Тени забытых статей ( о заражении Т-клеток, часть 4).
Авторы из Египта, решили проталкивать СD147 в качестве рецептора.
Для обоснования своих выводов они перелопатили ПабМед
и нашли себе доказательств :)
Тут сама статья
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223399/
В ней есть табличка.
И ссылки на призабытые первоисточники.
«Table 1. Proposed cell receptors for SARS-CoV-2 entry to T-cells»
Например на такой источник:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857060/
раздел "SARS-CoV-2 RNAs detected in multiple epithelial and immune cell types"
From the six BALF and two sputum samples of severe COVID-19 patients in the disease progression stage, we detected viral RNAs of SARS-CoV-2 in 3,085 cells from ciliated, secretory, and squamous epithelial cells and a diverse set of immune cells, including neutrophils, macrophages, plasma B cells, T cells, and NK cells (Figure 4 A; Table S4).
Fewer cells were obtained in BALF from moderate COVID-19 patients, and no SARS-CoV-2 RNA was detected.
The identity of these SARS-CoV-2-RNA-positive cells was confirmed by the corresponding marker genes (Figure 4B). Interestingly, immune cells harbored even more viral RNA sequences than epithelial cells (Figure 4C).
Because ACE2 and TMPRSS2 play critical roles in mediating SARS-CoV-2 entry (Hoffmann et al., 2020; Zhou et al., 2020), we examined their expression levels in these cells (Figure 4D).
We found that ACE2 and TMPRSS2 were expressed in a subset of these epithelial cells. However, immune cells did not express ACE2 or TMPRSS2. We then examined host factors recently reported to be relevant to SARS-CoV-2 entry in our data (Cantuti-Castelvetri et al., 2020; Daly et al., 2020; Singh et al., 2020; Tang et al., 2020)
and found that BSG and TFRC demonstrated correlations with the abundance of viral RNA in different cell types (Figures 4E and andS4 A).S4 A).
Consistently, independent scRNA-seq studies of COVID-19 patients also identified SARS-CoV-2 RNAs in neutrophils and macrophages (Bost et al., 2020; Chua et al., 2020).
Никто не скрывал заражение почти всех типов имм. клеток при ковиде .
Просто не подсвечивали ....
Цитата из первой, обзорной статьи
«A recent computational study identified a range of molecules, including adhesion molecules, chemokine receptors, and leukocyte surface molecules, as potential candidates that can interact with spike-RBD.
These molecules are expressed on most of the immune cell lineage. The findings showed that ACE2 had lower binding affinities with spike-RBD than XCR1,CD26, CD2, CD7, CD56, CCR9, CD150, CD4, CD50, and CD106 [201]
Although several of these molecules such as CD2, CD7, and CD4 are expressed by T- cells....»
Насчет обилия рецепторов описано что
«Furthermore, receptor-independent entry of coronaviruses has been documented for murine hepatitis virus (MHV) (38), MERS-CoV (35), and SARS-CoV-2 (39).»
https://journals.asm.org/doi/10.1128/spectrum.03483-22
Свиной "энцефалитный" вирус - вызывает реорганизацию актина
«These data provide strong evidence suggesting that the entry of PHEV into Neuro-2a cells relies critically on actin reorganization but is independent of macropinocytosis.»
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686734/