Reproducibility of research findings
Is Most Published Research Really False?
https://www.annualreviews.org/doi/abs/10.1146/annurev-statistics-060116-054104
Over the past decade, before pursuing a particular line of research, scientists (including C.G.B.) in the haematology and oncology department at the biotechnology firm Amgen in Thousand Oaks, California, tried to confirm published findings related to that work. Fifty-three papers were deemed ‘landmark’ studies (see ‘Reproducibility of research findings’). It was acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics. Nevertheless, scientific findings were confirmed in only 6 (11%) cases. Even knowing the limitations of preclinical research, this was a shocking result.
https://www.researchgate.net/publication/223989642_Drug_development_raise_standards_for_preclinical_cancer_research_Nature_4837391531-533_Epub_20120331
https://www.annualreviews.org/doi/abs/10.1146/annurev-statistics-060116-054104
Over the past decade, before pursuing a particular line of research, scientists (including C.G.B.) in the haematology and oncology department at the biotechnology firm Amgen in Thousand Oaks, California, tried to confirm published findings related to that work. Fifty-three papers were deemed ‘landmark’ studies (see ‘Reproducibility of research findings’). It was acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics. Nevertheless, scientific findings were confirmed in only 6 (11%) cases. Even knowing the limitations of preclinical research, this was a shocking result.
https://www.researchgate.net/publication/223989642_Drug_development_raise_standards_for_preclinical_cancer_research_Nature_4837391531-533_Epub_20120331