I've not really been drawn into many web comics. The only two I've so far actually liked have been about Mad Scientists.
Here's Agatha from
Girl Genius. I do love her. =)
This was inspired from a quote from someone somewhere about flamethrowers, something to the tune of that the very existence of flamethrowers implies that someone somewhere one day thought, 'Boy, I'd like to light those people over there on fire, too bad they're so far away.' Which is sick and twisted, but we like that. ;)
These guys are from
Miracle of Science, which has charming characters who seem to be over the age of 30, and a very intriguing storyline, and Mad Scientists. I love this one, too. It's sort of like what you'd get if Varley did romantic comedy.
And the other thing I'm loving these days is Fullmetal Alchemist, also chock full of Mad Scientists. Everybody likes Mad Scientists! =)