http://pyrsf.blogspot.com/2010/02/opening-floodgates-pyr-now-accepting.html Pyr books, a fairly big name in SF/F publishing, has starting accepting unagented manuscripts in certain circumstances:
"Unagented submissions: Email submissions ONLY-and ONLY in the subgenres of epic fantasy, sword & sorcery, and contemporary/urban fantasy. No horror, science fiction, or slipstream. Only full manuscripts accepted-no partials or outlines. Please send an email which includes your name, address, telephone number, and a one to three paragraph synopsis of your work, along with the manuscript attached as a Word doc or RTF file, to RSears at prometheusbooks dot com. Note that due to the volume of submissions a detailed reply in the case of a rejection may not be possible (and is unlikely)."
I don't have any complete manuscripts in those genres, so I won't be submitting to them, but as someone sending work out without having an agent, it's good to hear stuff like this :o)