S2 Translation (S2 Protein) into music

[themythicalman]

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From Colin Angus:

"The track 'S2 Translation' was generated from the DNA sequence and the amino acid characteristics of the S2 protein. The time signature of the piece is given by the codon: 3 base pairs per codon gives one codon per bar, hence the time signature is 3/4 or waltz time.The 'top line melody' comes directly from the base pair sequence itself (the bases cystosine, adenine, guanine and thymidine being mapped to the notes C, A G and E respectively) while progressions in the bass are reflective of the characteristics of the amino acids which are the result of translation. The number and nature of bass notes per codon/bar were determined by the hydrophobicity/hydrophilicity, ionic charge (positive or negative) and size of each amino acid residue (Proline, for example,which has no characteristics other than its small size, can be identified easily as the bars where the bass line 'drops out'). The musical output resulting from these rules was further processed by mapping the notes onto different tonalities, both to make the piece more interesting, and to suggest the organisation of the protein molecule into regions of different secondary structure (although since S2 is a membrane protein and thus impossible to crystallise outside the lipid bilayer, this was definitely creative licence).

S2 is the receptor protein for 5-hydroxy tryptamine (Serotonin) and presumably for other tryptamines as well. It is thus one of the most important molecules in the mediation of both ordinary and non-ordinary (or "Shamanic") states of consciousness, which is why the molecule was chosen for this piece."