So I am, as is my wont, totally unspoiled for S6. But I was on the phone with yesterday with a friend who's watched the S6 trailer, and she let slip
that Lisa does appear, in a fairly significant fashion.
...so now my SPN-deprived brain is in OVERDRIVE.
My current speculation: that Sam has indeed turned into a demon during his time in Hell, and he's casing out Lisa's house (per the end of 5.22) because he's going to PIN HER TO THE CEILING AND SET HER ON FIRE OMG.
So the arc-plot for S6 would be Dean hunting Sam. It'd be damn hard to pull off, not to mention to wrap in a way that allowed for an S7 but... OMG.
So excited for the premiere. I mean, I was before but... SO EXCITED.
...I think I'm going to cave and watch the trailer. If you've seen it: how spoilery is it, really?
I am (still) trying to stay unspoiled, so NO SPOILERS in the comments, please (but if you have fuelled-by-almost-nothing spec of your own, please share!)