I'd say something witty but I'm tired. Have a bunny.
1. G1/Deadpool fusion
Breakdown? Someone’s watching you…
Breakdown gains Deadpool’s ability to ’know’ the readers' presence. The rest of the cast is cheerfully oblivious.
This could be either hilarious or horrifying. Or both.
2. G1
The "Weapon of the Week" malfunctions. Contrary to all those times someone's been turned into a femme/sparkling/affected by lust-ray/etc. nothing happens. At all. It takes a while before they realise that.
3. Any
"Aliens made us do it!"
Humans + Autobots truth or dare game. Before the night is over, some very awkward explanations have to be made.
4. G1 AU
Some of the most important mechs of both factions were thrown into stasis four million years ago. Some hundreds of thousand years later, they were persumed dead. A little less than two million years ago, Shockwave approached Elita One with a proposition.
1984 some of the most important mechs of both factions exit stasis... having been found by an exploration team sent by the government of New Cybertron, an energy-rich planet, to see if the dominant species of the Earth, these humans, would make good allies against the Quintessons.
I've got more, but I've got to sleep now...