Нет, прогресс скорее в направлении улучшения и продления их функций. Во-первых, первая версия хорошо работала против свободных клеток и гораздо хуже против solid tumors, а новые вроде как намного лучше против solid. Во-вторых, делают так, чтобы в организме оставались клетки памяти этих супер-лимфоцитов, чтобы иммунная система могла позже сама активироваться если вдруг рак возвращается.
In this new study, Riddell says he's demonstrated in mice that the protein tag helps whip up potency, spur the proliferation of cells that fight cancer, cut back on manufacturing time from 14-20 days down to 9 days, and add a "kill switch" that can be used to deactivate the therapy if it threatens the patient.
That last bit about the safety switch is particularly significant, as the CAR-T approach is well known to spur cytokine release syndrome, also called a cytokine storm, which can and has killed patients.
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Там идет прогресс, но принцип остается тот же самый, детали наверно мало кому будут интересны.
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That last bit about the safety switch is particularly significant, as the CAR-T approach is well known to spur cytokine release syndrome, also called a cytokine storm, which can and has killed patients.
http://www.fiercebiotechresearch.com/story/juno-scientific-co-founder-stan-riddell-adds-another-upgrade-car-t/2016-02-24
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