http://www.engadget.com/2010/06/16/rock-band-3-squier-stratocaster-plays-both-real-and-virtual-guit/ So Rock Band 3? It has you playing real guitar. In fact, they're selling a Squier Strat with sensors and you can play through an amp while you're playing along with Rock Band. I wasn't sure how they'd show you the tab on-screen, but it's just guitar tab on the note highway.
I'm amazing they are pulling this off. I'll be investing in that guitar, even though it will cost too much.