So there's been talk about how Lucifer implied that he raped Sam while they were in the cage together. There's something else I'd like to point out--Lucifer seems to want to include Dean and make it a threesome. Watch where Dean is and where Lucifer points.
We don't see Luci pointing at Sam because his back is to the camera, but it's not much of a stretch to think he is from Sam's reaction.
Aaaand Lucifer just go a little creepier.