These are preliminary notes. I have only read the first three volumes, so please do not spoil me.
Gorgeous, gorgeous art and bishounen Cesare Borgia would probably be enough to addict me to this awesome quasi-historical manga; however, it also has accurate historical details interspersed with actual historical myths presented as facts, or at least I think it was a real legend that Cesare Borgia's father sold his son's soul to Satan so he (Borgia Senior) could become Pope. Oh, and it has an evil Pope! And Niccolo Machiavelli as a talking moth with a human head, or, as I like to call him, Mothiavelli.
And that's not all! There is incestuous longing between Cesare and his angelic blonde sister Lucrezia! (Yes, that Lucrezia Borgia.) Cesare's blood is a deadly poison! He has an extremely slashy relationship with the extremely pretty and surprisingly sweet boy Chiaro, who has a possibly magic mask which turns him into the deadly assassin Michelotto! Double-crossing, poisons, assassinations, and demonic magic abounds!
...Cesare's dead mother has been turned into a deadly zombie demon assassin, and he's about to go to Hell to meet Satan. Unless I misinterpreted something, which is always possible.
Really, there are not enough exclamation points for this series. And I'm told that it gets even better.
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Cantarella Volume 1 (Cantarella (Graphic Novel)) (v. 1)