Protease Inhibitor
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Alpha1 Antitrypsin
is an essential protease
inhibitor in blood plasma. It binds to a wide
range of proteases, such as elastase, trypsin,
chemotrypsin, thrombin, and bacterial proteases.
Its most important physiological effect is
the inhibition of leukocyte elastase, a protease
that breaks down the elastin of the pulmonary
alveolar walls. Deficiency of !1-antitrypsin
leads to increasing destruction of the pulmonary
alveoli, obstructive emphysema of the
lungs, and in newborns, a form of hepatitis.
Alpha1 Antitrypsin
is an essential protease
inhibitor in blood plasma. It binds to a wide
range of proteases, such as elastase, trypsin,
chemotrypsin, thrombin, and bacterial proteases.
Its most important physiological effect is
the inhibition of leukocyte elastase, a protease
that breaks down the elastin of the pulmonary
alveolar walls. Deficiency of !1-antitrypsin
leads to increasing destruction of the pulmonary
alveoli, obstructive emphysema of the
lungs, and in newborns, a form of hepatitis.