Sterile inflammation
Inflammation is triggered by intracellular molecules released from dying cells that have lost integrity of their plasma membrane. A number of intracellular molecules have been identified that can stimulate other cells to produce proinflammatory cytokines and chemokines. Such proinflammatory cellular molecules are thought to function by engaging receptors on cytokine-producing cells. One set of receptors that participates in this process and also in the response to infection are the TLRs.
From "The Inflammatory Response to Cell Death" Kenneth L. Rock and Hajime Kono, Annu. Rev. Pathol. Mech. Dis. 2008. 3:99-126
Questions
Do different cells have different intracellular proinflammatory molecules?
If yes, which molecules are more specific for neurons?
Do different conditions lead to the release of different intracellular mediators?
From "The Inflammatory Response to Cell Death" Kenneth L. Rock and Hajime Kono, Annu. Rev. Pathol. Mech. Dis. 2008. 3:99-126
Questions
Do different cells have different intracellular proinflammatory molecules?
If yes, which molecules are more specific for neurons?
Do different conditions lead to the release of different intracellular mediators?