This is a list of the 50 "most significant" science fiction/fantasy novels, 1953-2002, according to the Science Fiction Book Club. Bold the ones you've read, strike-out the ones you hated, italicize those you started but never finished, and put an asterisk* beside the ones you loved.
The Lord of the Rings, J.R.R. Tolkien (I just found these books boring. The fact that I was middle or elementary school at the time may have contributed.)
The Foundation Trilogy, Isaac Asimov
Dune, Frank Herbert (The first book was okay, but the ending of the second or third irritated me enough to make me stop reading the series.)
Stranger in a Strange Land, Robert A. Heinlein
A Wizard of Earthsea, Ursula K. Le Guin
Neuromancer, William Gibson
Childhood's End, Arthur C. Clarke (Third grade for this one, I think. I just skipped to the end.)
Do Androids Dream of Electric Sheep?, Philip K. Dick (I dislike books where the sole motivation of the protagonist seems to be to angst about their existence until the plot forces them to do something.)
The Mists of Avalon, Marion Zimmer Bradley
Fahrenheit 451, Ray Bradbury
The Book of the New Sun, Gene Wolfe
A Canticle for Leibowitz, Walter M. Miller, Jr.
The Caves of Steel, Isaac Asimov
Children of the Atom, Wilmar Shiras
Cities in Flight, James Blish
The Colour of Magic, Terry Pratchett* (Such a fan of Terry Pratchett)
Dangerous Visions, edited by Harlan Ellison
Deathbird Stories, Harlan Ellison
The Demolished Man, Alfred Bester
Dhalgren, Samuel R. Delany
Dragonflight, Anne McCaffrey*
Ender's Game, Orson Scott Card*
The First Chronicles of Thomas Covenant the Unbeliever, Stephen R. Donaldson (I hear I should read this)
The Forever War, Joe Haldeman
Gateway, Frederik Pohl
Harry Potter and the Philosopher's Stone, J.K. Rowling
The Hitchhiker's Guide to the Galaxy, Douglas Adams*
I Am Legend, Richard Matheson
Interview with the Vampire, Anne Rice
The Left Hand of Darkness, Ursula K. Le Guin (Sitting on my bookshelf right now).
Little, Big, John Crowley
Lord of Light, Roger Zelazny (I liked Amber better, though.)
The Man in the High Castle, Philip K. Dick
Mission of Gravity, Hal Clement
More Than Human, Theodore Sturgeon
The Rediscovery of Man, Cordwainer Smith
On the Beach, Nevil Shute
Rendezvous with Rama, Arthur C. Clarke (I don't remember why exactly I didn't like this.)
Ringworld, Larry Niven*
Rogue Moon, Algis Budrys
The Silmarillion, J.R.R. Tolkien
Slaughterhouse-5, Kurt Vonnegut
Snow Crash, Neal Stephenson*
Stand on Zanzibar, John Brunner
The Stars My Destination, Alfred Bester
Starship Troopers, Robert A. Heinlein
Stormbringer, Michael Moorcock
The Sword of Shannara, Terry Brooks
Timescape, Gregory Benford
To Your Scattered Bodies Go, Philip Jose Farmer