Systemic integration of different inheritance systems

Apr 25, 2024 21:54


Theoretical rethinking of adaptive teleometry in life complication process via structural  analysis of evolution of framing conditions of stress-reactive behavior of the main actors of  the system  Here and after the following definition of behavior is used “ behaviour is the range of actions and  mannerisms made by individuals, organisms, systems, or artificial entities in conjunction with  themselves or their environment, which includes the other systems or organisms around as well as the  (inanimate) physical environment. It is the response of the system or organism to various stimuli or  inputs, whether internal or external, conscious or subconscious, overt or covert, and voluntary or  involuntary (Elizabeth A. Minton, Lynn R. Khale (2014). Belief Systems, Religion, and Behavioral  Economics. New York: Business Expert Press LLC. ISBN 978-1-60649-704-3.) ..... for reading further https://www.academia.edu/92096358/Rrefbehfinrecon_ev_ene_work_stress

Systemic integration of different inheritance systems Eva Jablonka and Denis Noble https://www.academia.edu/116440377/Systemic_integration_of_different_inheritance_systems?email_work_card=view-paper

Abstract



The between-generations transmission of phenotypic variations is based on networks operating at different levels-genetic, epigenetic, behavioral and symbolic. Since each level involves a network of interactions, integrating suchnetworks of networks may seem hopelessly complex. We suggest that the problem can be drastically simplified if analysis starts from a description of the heritable trait of interest asan attractor in a developmental landscape constructed bynetworks of inputs at underlying and overlying levels of organization. On this basis, further studies quantifying the different inputs that contribute to the between-generational re-construction of the trait can be made and enable the development of a systemic, dynamic and predictive model of inheritance.

Introduction

There are two broad ways to think about the inheritance of phenotypes. The first and most familiar is the exclusive genetic approach. With the exception of the

inheritance of cultural variations, the inheritance of phenotypes is described in terms of genetic variations onthe assumption that variations in heritable phenotypic traits (heritably varying traits: HVTs; all bold, key concepts, are defined in Box 1) can be fully mapped to DNA sequence variations. This approach has been challenged, since today it is clear that inheritance includes the transmission of variations that are not based solely on differences in DNA base sequences: two individuals with identical DNA sequences can pass different developmentally acquired variations to theirdescendants, sometimes for many generations.  The second approach is described by developmental systemstheory (DST) [1], in which heredity is seen as a complex system of interacting inheritance systems at different levels (genetic, epigenetic, behavioral and symbolic)

[2]. We adopt this multi-level approach in this paper andargue that it is the HVT e embedded within the lifecycle of the individual e that should be the unit of analysis [3] rather than any of the specific inputs into it (e.g., the gene, the epiallele, the “meme”). We use two hypothetical examples to illustrate how inputs atdifferent levels contribute to the inheritance of a phenotypic trait e a food preference.1 We then describe a systems biology approach to inclusive inheritancebased on Waddington’s epigenetic landscape model, andpoint to methodologies that quantify and tease apart some of the heritable inputs into a trait’s development and inheritance.

Syst_integrationJablNoble

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