Planning, Fretting, Relaxing and Coveting...
...all things i''ve been doing since I got back to Glasgow.
The train journey yesterday was arduous. 6hrs 20mins long it was and the one change I opted for was pretty much 2-3 stations out of Notts, about 30 minutes journey. I have sussed that this was an unwise move because sitting on a train for the remaining 6 hours in one seat is officially crippling! I was really achy last night and today I just *feel* exhausted. Perhaps that's the two weeks catching up on me rather than the rather uneventful train journey.
As I mentioned in the previous post, James is due a visit to Glasgow in August. This is a nice treat for me as I usually do the travelling because he has to work around his job, the one where the people take him for granted and I get pissed off and he just accepts it because it's "money" >.< Anyhoo, beside the point. He's booked a week off the 2nd week in August, time off in summer is a totally novel concept to him because for some reason, only known to himself, he takes all his holidays towards the end of the year (but not around christmas because "that would be pointless" as he does nothing at work then anyway). Whilst he's up though I made the suggestion that we do something fun; spend a day doing something as a couple, but for the life of me couldn't think of anything worthwhile that Glasgow had to offer :/ That's probably really terrible to say and if anyone cares to enlighten me, then feel free. I did however discover a pub worth trying, which i'm going to source out at some point - Cask and Still. Apparently it has over 160 different kind of malts and James likes whiskey, preferably single malts. This pub's on Hope Street, so sometime soon i'll take a trip into town and see if it looks worthy of an evening out, maybe with Gondor or Mark or something :)
Keeping with the whiskey theme we're going out to Glengoyne Distillery (http://www.glengoyne.com/index.php) for a morning/afternoon and participating in a tour where there is tasting afterwards and whilst speaking to Vati about it he recommended an excellent pub called The Beech Tree Inn (http://thebeechtreeinn.co.uk/index.php) just down the road which apparently serves fantastic food, so we can maybe grab some lunch afterwards. If the weathers nice we might even head on out to Loch Lomond for a bit, take some photographs and things and just have a nice, potentially romantic, day out :)
James seemed really keen when I ran it past him earlier, so regardless of weather the distillery and pub is a go!
This all kicked off one night when we were trying to get to sleep and having our usual, nightly "chat" before dropping off and I happened to mention that 3 things I definitely want to do in life is ride horses again, drive a tank and fly a plane. We started discussing tanks and planes and how I've always meant to go to the air show at the airforce base over near St Andrews and he said "Duxford is pretty cool, I'll take you there sometime. It's an aircraft museum back home in Cambridge" So the plan is, next time i'm down, we're heading to Cambridge for a weekend, probably crash at his dads, and go check out this museum :) (http://duxford.iwm.org.uk/) Sweet of him I thought. He's been before, a few times, and there are air shows there too which he thinks are pretty awesome so i'm rather looking forward to that :) Showing me what his hometown has to offer prompted me into showing him Glasgow's finery and promptly came up blank. Glasgows beauty is around it, like Loch Lomond and this distillery, not really in the city itself. I mean the architechtural stuff is neat for photographers, but possibly not the most fun or romantic thing to do. I will take photos though, I WILL *tattoos it to self*
I spent most of yesterday taking it easy and coveting new clothes which will have to wait until a much later date for purchase whilst trying to block out the thought of this really horrible medication >.< Up until now - reasonable brave face. I'm over it. I'm actually shitting bricks. Tuesday is delivery day and Joanne(?), the nurse, is to phone to arrange a time to come the following day. The thought of ALL the complications that could occur by injecting myself with this drug makes me feel physically sick. I tried so fucking hard to make James believe it would all be ok and I "think" it worked to some degree, but how the hell I managed (if i did), I don't know, because i'm not sure *I* believed what I was saying.
Quick run down:
Infections
Patients taking TNF-blockers are more susceptible to serious infections. Patients must therefore be monitored closely for infections, including tuberculosis, before, during and after treatment with Humira. Because the elimination of adalimumab may take up to five months, monitoring should be continued throughout this period.
Serious infections:
Serious infections, including sepsis, due to bacterial, mycobacterial, invasive fungal viral, or other opportunistic infections such as listeriosis, and pneumocystis have been reported in patients receiving Humira. Other serious infections seen in clinical trials include pneumonia, pyelonephritis, septic arthritis and septicaemia. Hospitalisation or fatal outcomes associated with infections have been reported.
Tuberculosis:
There have been reports of tuberculosis in patients receiving Humira. It should be noted that in the majority of those reports, tuberculosis was extra-pulmonary, i.e. disseminated.- >.<
Other opportunistic infections:
Opportunistic infections, including invasive fungal infections have been observed in patients receiving Humira. These infections have not consistently been recognised in patients taking TNF-blockers and this resulted in delays in appropriate treatment, sometimes resulting in fatal outcomes. For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnea, and/or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasivie fungal infection should be suspected and administration of Humira should be promptly discontinued and appropriate antifungal therapy should be initiated. - Man...this is going to be hardcore sucky. That excitement I spoke of is GONE.
Neurological events
TNF-antagonists including Humira have been associated in rare instances with new onset or exacerbation of clinical symptoms and/or radiographic evidence of demyelinating disease including multiple sclerosis. - O.o
Allergic reactions
Serious allergic adverse reactions have not been reported with subcutaneous administration of Humira during clinical trials. Non-serious allergic reactions associated with Humira were uncommon during clinical trials. In postmarketing, serious allergic reactions including anaphylaxis have been reported very rarely following Humira administration. - If it's not one thing it's another...
Malignancies and lymphoproliferative disorders
In the controlled portions of clinical trials of TNF-antagonists, more cases of malignancies including lymphoma have been observed among patients receiving a TNF-antagonist compared with control patients. However, the occurrence was rare. Furthermore, there is an increased background lymphoma risk in rheumatoid arthritis patients with long-standing, highly active, inflammatory disease, which complicates the risk estimation. Rare postmarketing cases of hepatosplenic T-cell lymphoma have been identified in patients treated with adalimumab. This rare type of T-cell lymphoma has a very aggressive disease course and is usually fatal. - This scares the living shit out of me.
Haematologic reactions
Rare reports of pancytopenia including aplastic anaemia have been reported with TNF antagonists. Adverse events of the haematologic system, including medically significant cytopoenia (e.g. thrombocytopaenia, leucopaenia) have been infrequently reported with Humira. All patients should be advised to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias (e.g. persistent fever, bruising, bleeding, pallor) while on Humira.- christ!
Autoimmune processes
Treatment with Humira may result in the formation of autoimmune antibodies. The impact of long-term treatment with Humira on the development of autoimmune diseases is unknown. If a patient develops symptoms suggestive of a lupus-like syndrome following treatment with Humira and is positive for antibodies against double-stranded DNA, further treatment with Humira should not be given. - Er...being given this FOR an autoimmune disease and they don't know what long term effects it'll have on me, wonderful.
Surgery
There is limited safety experience of surgical procedures in patients treated with Humira. The long half-life of adalimumab should be taken into consideration if a surgical procedure is planned. - Great! Let's hope I don't need emergency surgery.
Read more: http://emc.medicines.org.uk/medicine/21201#ixzz0L6DUgNTo&C
Now I think you'll understand the fretting going on. Man, i should really get to sleep and just think happy thoughts. Easier said than done. James - August - Distillery etc *mantra*.
The train journey yesterday was arduous. 6hrs 20mins long it was and the one change I opted for was pretty much 2-3 stations out of Notts, about 30 minutes journey. I have sussed that this was an unwise move because sitting on a train for the remaining 6 hours in one seat is officially crippling! I was really achy last night and today I just *feel* exhausted. Perhaps that's the two weeks catching up on me rather than the rather uneventful train journey.
As I mentioned in the previous post, James is due a visit to Glasgow in August. This is a nice treat for me as I usually do the travelling because he has to work around his job, the one where the people take him for granted and I get pissed off and he just accepts it because it's "money" >.< Anyhoo, beside the point. He's booked a week off the 2nd week in August, time off in summer is a totally novel concept to him because for some reason, only known to himself, he takes all his holidays towards the end of the year (but not around christmas because "that would be pointless" as he does nothing at work then anyway). Whilst he's up though I made the suggestion that we do something fun; spend a day doing something as a couple, but for the life of me couldn't think of anything worthwhile that Glasgow had to offer :/ That's probably really terrible to say and if anyone cares to enlighten me, then feel free. I did however discover a pub worth trying, which i'm going to source out at some point - Cask and Still. Apparently it has over 160 different kind of malts and James likes whiskey, preferably single malts. This pub's on Hope Street, so sometime soon i'll take a trip into town and see if it looks worthy of an evening out, maybe with Gondor or Mark or something :)
Keeping with the whiskey theme we're going out to Glengoyne Distillery (http://www.glengoyne.com/index.php) for a morning/afternoon and participating in a tour where there is tasting afterwards and whilst speaking to Vati about it he recommended an excellent pub called The Beech Tree Inn (http://thebeechtreeinn.co.uk/index.php) just down the road which apparently serves fantastic food, so we can maybe grab some lunch afterwards. If the weathers nice we might even head on out to Loch Lomond for a bit, take some photographs and things and just have a nice, potentially romantic, day out :)
James seemed really keen when I ran it past him earlier, so regardless of weather the distillery and pub is a go!
This all kicked off one night when we were trying to get to sleep and having our usual, nightly "chat" before dropping off and I happened to mention that 3 things I definitely want to do in life is ride horses again, drive a tank and fly a plane. We started discussing tanks and planes and how I've always meant to go to the air show at the airforce base over near St Andrews and he said "Duxford is pretty cool, I'll take you there sometime. It's an aircraft museum back home in Cambridge" So the plan is, next time i'm down, we're heading to Cambridge for a weekend, probably crash at his dads, and go check out this museum :) (http://duxford.iwm.org.uk/) Sweet of him I thought. He's been before, a few times, and there are air shows there too which he thinks are pretty awesome so i'm rather looking forward to that :) Showing me what his hometown has to offer prompted me into showing him Glasgow's finery and promptly came up blank. Glasgows beauty is around it, like Loch Lomond and this distillery, not really in the city itself. I mean the architechtural stuff is neat for photographers, but possibly not the most fun or romantic thing to do. I will take photos though, I WILL *tattoos it to self*
I spent most of yesterday taking it easy and coveting new clothes which will have to wait until a much later date for purchase whilst trying to block out the thought of this really horrible medication >.< Up until now - reasonable brave face. I'm over it. I'm actually shitting bricks. Tuesday is delivery day and Joanne(?), the nurse, is to phone to arrange a time to come the following day. The thought of ALL the complications that could occur by injecting myself with this drug makes me feel physically sick. I tried so fucking hard to make James believe it would all be ok and I "think" it worked to some degree, but how the hell I managed (if i did), I don't know, because i'm not sure *I* believed what I was saying.
Quick run down:
Infections
Patients taking TNF-blockers are more susceptible to serious infections. Patients must therefore be monitored closely for infections, including tuberculosis, before, during and after treatment with Humira. Because the elimination of adalimumab may take up to five months, monitoring should be continued throughout this period.
Serious infections:
Serious infections, including sepsis, due to bacterial, mycobacterial, invasive fungal viral, or other opportunistic infections such as listeriosis, and pneumocystis have been reported in patients receiving Humira. Other serious infections seen in clinical trials include pneumonia, pyelonephritis, septic arthritis and septicaemia. Hospitalisation or fatal outcomes associated with infections have been reported.
Tuberculosis:
There have been reports of tuberculosis in patients receiving Humira. It should be noted that in the majority of those reports, tuberculosis was extra-pulmonary, i.e. disseminated.- >.<
Other opportunistic infections:
Opportunistic infections, including invasive fungal infections have been observed in patients receiving Humira. These infections have not consistently been recognised in patients taking TNF-blockers and this resulted in delays in appropriate treatment, sometimes resulting in fatal outcomes. For patients who develop the signs and symptoms such as fever, malaise, weight loss, sweats, cough, dyspnea, and/or pulmonary infiltrates or other serious systemic illness with or without concomitant shock an invasivie fungal infection should be suspected and administration of Humira should be promptly discontinued and appropriate antifungal therapy should be initiated. - Man...this is going to be hardcore sucky. That excitement I spoke of is GONE.
Neurological events
TNF-antagonists including Humira have been associated in rare instances with new onset or exacerbation of clinical symptoms and/or radiographic evidence of demyelinating disease including multiple sclerosis. - O.o
Allergic reactions
Serious allergic adverse reactions have not been reported with subcutaneous administration of Humira during clinical trials. Non-serious allergic reactions associated with Humira were uncommon during clinical trials. In postmarketing, serious allergic reactions including anaphylaxis have been reported very rarely following Humira administration. - If it's not one thing it's another...
Malignancies and lymphoproliferative disorders
In the controlled portions of clinical trials of TNF-antagonists, more cases of malignancies including lymphoma have been observed among patients receiving a TNF-antagonist compared with control patients. However, the occurrence was rare. Furthermore, there is an increased background lymphoma risk in rheumatoid arthritis patients with long-standing, highly active, inflammatory disease, which complicates the risk estimation. Rare postmarketing cases of hepatosplenic T-cell lymphoma have been identified in patients treated with adalimumab. This rare type of T-cell lymphoma has a very aggressive disease course and is usually fatal. - This scares the living shit out of me.
Haematologic reactions
Rare reports of pancytopenia including aplastic anaemia have been reported with TNF antagonists. Adverse events of the haematologic system, including medically significant cytopoenia (e.g. thrombocytopaenia, leucopaenia) have been infrequently reported with Humira. All patients should be advised to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias (e.g. persistent fever, bruising, bleeding, pallor) while on Humira.- christ!
Autoimmune processes
Treatment with Humira may result in the formation of autoimmune antibodies. The impact of long-term treatment with Humira on the development of autoimmune diseases is unknown. If a patient develops symptoms suggestive of a lupus-like syndrome following treatment with Humira and is positive for antibodies against double-stranded DNA, further treatment with Humira should not be given. - Er...being given this FOR an autoimmune disease and they don't know what long term effects it'll have on me, wonderful.
Surgery
There is limited safety experience of surgical procedures in patients treated with Humira. The long half-life of adalimumab should be taken into consideration if a surgical procedure is planned. - Great! Let's hope I don't need emergency surgery.
Read more: http://emc.medicines.org.uk/medicine/21201#ixzz0L6DUgNTo&C
Now I think you'll understand the fretting going on. Man, i should really get to sleep and just think happy thoughts. Easier said than done. James - August - Distillery etc *mantra*.