Bioavailability ? Drug interactions - organic nitrates It works by inhibiting an enzyme known as PDE5. A 20 mg dose of Tadalafil is comparable to a 100 mg dose of sildenafil (Viagra). Contents [hide] Legal status
1 Tadalafil at work [edit]
PubChem 110635 7 External links Jump to: navigation, search
Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina (GTN Spray), these patients should seek immediate medical attention if they experience anginal chest pain [1]. In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil. DrugBank APRD00071 The empirical formula for tadalafil is C22H19N3O4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazino[1 ,2 :1,6]pyrido[3,4-b]indole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses. Pharmacokinetic data Pregnancy cat. ?
Side effects (6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1', 2':1,6] pyrido[3,4-b]indole-1,4-dione 3 Side effects (Redirected from Cialis) [edit]
5 Marketing Excretion ? Formula C22H19N3O4 Tadalafil Chemical data
[edit]
[edit] ATC code G04BE08
In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, including diabetics. An investigation is currently ongoing. Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates (such as the sex drug Amyl nitrite) within this timeframe may increase the risk of life-threatening hypotension. Trivia [edit]
Metabolism ? CAS number 171596-29-5 From Wikipedia, the free encyclopedia [edit] 4 Drug interactions - organic nitrates Identifiers 2 Chemical information The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.
Systematic (IUPAC) name Mol. weight 389.404 g/mol Tadalafil Therapeutic considerations External links Protein binding 94% 6 Trivia In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third pill after Viagra and Levitra. Due to its 36-hour effect it is also known as the "Weekend Pill". [edit] Tadalafil at work Routes ?
Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis.
Some individuals with the surname of "Cialis" objected to the naming of Lilly's drug, but the pharmaceutical giant insists that the drug's name has nothing to do with the surname. [2] Marketing Chemical information
In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR. Half life 17.5 hours +4186.4013671875
Drug interactions - organic nitrates
It works by inhibiting an enzyme known as PDE5. A 20 mg dose of Tadalafil is comparable to a 100 mg dose of sildenafil (Viagra).
Contents [hide]
Legal status
1 Tadalafil at work
[edit]
PubChem 110635
7 External links
Jump to: navigation, search
Since people who have taken tadalafil within the past 48 hours cannot take organic nitrates to relieve angina (GTN Spray), these patients should seek immediate medical attention if they experience anginal chest pain [1]. In the event of a medical emergency, paramedics and medical personnel should be notified of any recent doses of tadalafil.
DrugBank APRD00071
The empirical formula for tadalafil is C22H19N3O4, and its official organic name is (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methyl-pyrazino[1 ,2 :1,6]pyrido[3,4-b]indole-1,4-dione. The molecular weight is 389.41. The tablets are yellow, film-coated, and almond-shaped, and are produced in 5, 10, or 20mg doses.
Pharmacokinetic data
Pregnancy cat. ?
Side effects
(6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1', 2':1,6] pyrido[3,4-b]indole-1,4-dione
3 Side effects
(Redirected from Cialis)
[edit]
5 Marketing
Excretion ?
Formula C22H19N3O4
Tadalafil
Chemical data
[edit]
[edit]
ATC code G04BE08
In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) could lead to vision impairment in certain patient groups, including diabetics. An investigation is currently ongoing.
Since PDE5 inhibitors such as tadalafil may cause transiently low blood pressure (hypotension), organic nitrates should not be taken for at least 48 hours after taking the last dose of tadalafil. Using organic nitrates (such as the sex drug Amyl nitrite) within this timeframe may increase the risk of life-threatening hypotension.
Trivia
[edit]
Metabolism ?
CAS number 171596-29-5
From Wikipedia, the free encyclopedia
[edit]
4 Drug interactions - organic nitrates
Identifiers
2 Chemical information
The most common side effects when using tadalafil are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking the drug, and the symptom usually goes away after 48 hours.
Systematic (IUPAC) name
Mol. weight 389.404 g/mol
Tadalafil
Therapeutic considerations
External links
Protein binding 94%
6 Trivia
In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third pill after Viagra and Levitra. Due to its 36-hour effect it is also known as the "Weekend Pill".
[edit]
Tadalafil at work
Routes ?
Tadalafil is a drug used to treat male erectile dysfunction (impotence). It was developed by the biotechnology firm ICOS and marketed worldwide by Eli Lilly and Company under the brand name Cialis.
Some individuals with the surname of "Cialis" objected to the naming of Lilly's drug, but the pharmaceutical giant insists that the drug's name has nothing to do with the surname. [2]
Marketing
Chemical information
In the United States, Eli Lilly has a multiyear agreement to promote tadalafil (Cialis) with professional golf's PGA TOUR.
Half life 17.5 hours +4186.4013671875
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