(no subject)
I was about Inflammation and Stem Cells in
Gastrointestinal Carcinogenesis, one of the first points this article
makes is that cancers have a higher tendency to arise in response to
chronic inflammation.
At work, a number of people in my office (including myself) work on
HIV research, and I remember reading somewhere that HIV causes chronic
inflammation. On top of this, my lab director got me interested in
the question of where HIV hangs out in the body during latent phases .
Combining these two ideas, I wonder if you would see a higher
incidence of cancers arising in individuals who have been on ART for a
long time (say, the 10-20 years it would take for a cancer to arise),
who are responding well to that treatment and so they are still
immunocompetent.
My question would be whether, if you took a look at the rate of
incidences in these people, you would find in that population a higher
incidence of cancers located at and around the sites where HIV is
being expressed at low levels associated with latency?
Any thoughts or ideas?
Gastrointestinal Carcinogenesis, one of the first points this article
makes is that cancers have a higher tendency to arise in response to
chronic inflammation.
At work, a number of people in my office (including myself) work on
HIV research, and I remember reading somewhere that HIV causes chronic
inflammation. On top of this, my lab director got me interested in
the question of where HIV hangs out in the body during latent phases .
Combining these two ideas, I wonder if you would see a higher
incidence of cancers arising in individuals who have been on ART for a
long time (say, the 10-20 years it would take for a cancer to arise),
who are responding well to that treatment and so they are still
immunocompetent.
My question would be whether, if you took a look at the rate of
incidences in these people, you would find in that population a higher
incidence of cancers located at and around the sites where HIV is
being expressed at low levels associated with latency?
Any thoughts or ideas?