The Top 10 OMGWTF Moments in Gaming by Screw Attack.
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Currently, at 2:30am, I'm finding this video incredibly amusing. I'm not enough of a geek to have experienced most of these moments, however I do recall the Call of Duty 4 scene when I watched my brother play it, as well as having vivid memories of my 14 year old self being quite distraught over Aerith's death in Final Fantasy VII. I swear Final Fantasy games always make me cry.