Ooh. I knew that a large proportion of wikipedia would be composed of horrible diseases, and here's the first
optic atrophy is atrophy of the optic nerve, although it's suggested that "atrophy" is the wrong word and it should be called "neuropathy", since atrophied body parts (e.g. muscles) can usually regrow, but the optic nerve can't. Unsurprisingly, symptoms include blindness.
Of course, the real question when you learn about a new horrible disease is: do I have it? According to my eye test of two weeks ago I can still see, so I don't have the most common childhood-onset congenital form. But there's another form which has its onset in 20-30 year old males. Holy crap, I'm a 20-30 year old male!