Regarding the Orlando Attacks ...
What you're seeing here is the Caliphate attempting to enforce its laws -- shari'a -- in Western societies by means of terrorist attack. This is part of a wave of terrorism they explicitly called for, to be launched during Ramadan. And in shari'a, homosexuality is punishable by death.
This target was cleverly-chosen, because the point is to get some Westerners who hate homosexuals, to sympathize with the motives of the attackers. Also, gays are at least perceived to be politically-vulnerable, because their political allies are unwilling or unable to do anything against Muslim anti-homosexuals, as it will offend Muslims (the Muslim radicals, watching our system from the outside, don't realize that gays don't vote as a bloc).
Unless we as a nation act effectively to block terrorist entry into America, and the radicalization of Muslims in America by ending the idea of "different culture" as a de facto exculpatory factor; and in cases like this respond with massive and deliberately over-proportionate retaliation against the foreign sponsors (where present), these attacks will continue. Islam will [i]always[/i] find lunatics whose mad hate can be encouraged, rather than suppressed, by a religion largely built around hatred; and they can be primed and shot off like rounds of ammunition against us -- and worse, like precision guided munitions, against the parts of our society which they don't like.
Worse, because it means that they will change us to be more like them.
Have you enjoyed the last 40 or so years of freedom to be openly gay, a freedom unprecedented in the history of the West, maybe of civilization? Do you want to keep it?
Then be prepared to fight for it, because Islam does not mean that you should keep it.
That is the significance of what happened in Orlando, and what has already begun happening in London and many other places in Europe.
FIght, or lose your freedom.