"Baba Yetu," the title theme from Civilization IV, is the first video game song in history to be nominated for a Grammy Award.
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Saw it performed twice in person, once by the Los Angeles Philharmonic and another by the San Diego Symphony. It's always been one of my favorites, so this development pleases me greatly.
(For friends who are so inclined, you may be interested to note that the lyrics are the Swahili version of the Lord's Prayer.)