Spoilers - TV Guide
Any Gossip Girl scoop? Nate and Serena aren't hooking up for season finale, right? - Daniel
MICKEY: No! That would never happen! I mean, Nate and Serena would totally be the least likely couple in all of Gossip-dom, especially considering their sleazy history. It would be totally unexpected, right? Plus, when I mentioned that the producers should fix Gossip Girl by dirtying up fuzzy bunnies Serena and Nate, it's not like the powers that be were listening. Right? Right?
Source
Nate should just end the season alone. Too many girls in one season!