4.08 vs 4.18
4.08 Juliet Doesn't Live Here Anymore
Serena: I was running away from someone and I ran straight into you.
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Serena: That’s a horrible idea! You’re a good person. Someone deserves to have you do more then put them in a cab.
Colin: Good Luck Serena.
4.18 The Kids Stay in the Picture
Dan: Blair your prince is out there waiting for you. It might not me be or Chuck but he’s out there.
Blair: Your princess is too, if you’re ready for her.
I really did/do like both these couples! Then they (the writers) just completely disregard their relationship, make blatant references to Derena and wish each other off on their merry way.