http://www.animenewsnetwork.com/news/2009-03-06/fullmetal-alchemist-2009-anime-cast-revealed They recast almost everyone except for Al, Ed & Hughes. I see a lot of people from Gundam 00 there, so the Sunday afternoon 5pm audience would probably get a lot of dejavu. MikiShin as Mustang seems like they're going to emphasize his playboy-ness? I like Okawa Tohru but he does seem too old for Roy. Too bad Michiko Neya got replaced, I think she was a perfect Hawkeye (and her+MikiShin = Lyle/Shirin XD even the personalities are a bit similar). But Orikasa Fumiko is usually good. Kikuko Inoue as Lust sounds good. Hiroyuki Yoshino as Kimblee = Hallelujah voiceeeee.
And I don't remember who Isaac is.