I wonder if this has been done before

[floriatosca]

There was a multifandom challenge a while back, to write AU stories where a character was a brain in a jar hooked up to the inner workings of a spaceship (or, in one case, the author went for a retro feel and had the character in question wired into a highly experimental WWII fighter plane), and some of the results were pretty awesome. There's

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[pukingtoreador]

I still wish you'd do Sing On Oh Muse. You have such kickass ideas.

[floriatosca]

I haven't given up on it (although other stuff is currently taking up most of my brain space).