From WB's twitter:
source Also Universal has made a website for casting Sam St. Cloud:
http://www.iamsamstcloud.com.
If you go to the site, you can download the sides for Sam and get a little bit of insight into what changes have been made in the transition from novel to screenplay.
ETA: comingsoon.net mentions, "Please note that all who audition must be available for work from July 2009 through October 2009," which fits what we've heard.