Jul 05, 2004 13:29
somnambulism
A condition of the nervous system in which an individual during sleep performs actions approppriate to the waking state; a state of sleep in which some of the senses and voluntary powers are partially awake; noctambulism.
Last night I had chicken soup for dinner, I enjoyed it.
I wonder if I should cook fish tonight?
sickle cell anaemia
The cause is a point mutation in the allele that codes for the beta chain of haemoglobin with a substitution of (valine for glutamic acid at position 6. The defective haemoglobin (HbS) crystallizes readily at low oxygen tension.
In consequence, erythrocytes from homozygotes change from the normal discoid shape to a sickled shape when the oxygen tension is low and these sickled cells become trapped in capillaries or damaged in transit, leading to severe anaemia.
In heterozygotes, the disadvantages of the abnormal haemoglobin are apparently outweighed by increased resistance to Plasmodium falciparum malaria, probably because parasitised cells tend to sickle and are then removed from circulation.
Symptoms include joint pain, acute abdominal pain, and ulcerations of the lower extremities.