Exmh uses the regular MH programs to manipulate your mail folders and messages. This means it is compatible with command-line use of MH programs, and its actions should be familiar if you are an experienced MH user. If you are a new MH user, then the details of running MH programs is hidden behind the graphical interface.
Yet another package suggestion from Robert Waldner:
exmh is a graphical frontend to (n)mh, a mail-system that stores every mail in a single, plain-text, file, but without the complexity that is maildir. It's special strength is in preserving your sanity even if you get 2k+ emails/day. You get all the features of a graphical MUA but (IMHO) without the usual downsides. It's also happy with more than one instance of it running. And you don't have to learn Emacs just for a MUA. Plus it's easily combinable with kuvert, which'll transparently handle GnuPG/PGP signing and/or encrypting depending on your preferences and the recipients capabilities.
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Debian web site.
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