The Top 50 Pharmaceutical Companies by Research and Development Investment
Pharma Rank
World Rank
Company
Country
€ million
1
6
ROCHE
Switzerland
7007.8
2
7
NOVARTIS
Switzerland
6922.8
3
8
MERCK US
USA
5995.9
4
9
JOHNSON & JOHNSON
USA
5809.5
5
10
PFIZER
USA
5740.5
6
15
SANOFI-AVENTIS
France
4909.0
7
20
GLAXOSMITHKLINE
UK
4229.0
8
26
ELI LILLY
USA
4000.4
9
33
ASTRAZENECA
UK
3375.0
10
35
ABBOTT LABORATORIES
USA
3275.9
11
36
BAYER
Germany
3182.0
12
40
BRISTOL-MYERS SQUIBB
USA
2851.3
13
41
TAKEDA PHARMACEUTICAL
Japan
2839.8
14
42
BOEHRINGER INGELHEIM
Germany
2795.0
15
47
AMGEN
USA
2561.8
16
67
OTSUKA
Japan
1684.5
17
68
DAIICHI SANKYO
Japan
1602.9
18
69
ASTELLAS PHARMA
Japan
1593.4
19
72
MERCK DE
Germany
1511.3
20
78
NOVO NORDISK
Denmark
1397.4
21
81
GILEAD SCIENCES
USA
1333.9
22
87
CELGENE
USA
1205.8
23
107
EISAI
Japan
1054.1
24
110
BIOGEN IDEC
USA
1011.8
25
114
TEVA PHARMACEUTICAL INDUSTRIES
Israel
972.4
26
126
SERVIER
France
862.0
27
145
UCB
Belgium
782.0
28
148
ALLERGAN
USA
750.0
29
161
FOREST LABORATORIES
USA
676.5
30
165
SHIRE
UK
660.8
31
177
VERTEX PHARMACEUTICALS
USA
571.5
32
214
SHIONOGI
Japan
464.3
33
245
ONO PHARMACEUTICAL
Japan
397.9
34
253
ACTELION
Switzerland
380.8
35
279
H LUNDBECK
Denmark
338.4
36
298
ZOETIS
USA
310.0
37
302
HOSPIRA
USA
304.8
38
303
WATSON PHARMACEUTICALS
USA
304.5
39
308
MYLAN
USA
294.8
40
329
CSL
Australia
280.0
41
334
IPSEN
France
275.3
42
345
LIFE TECHNOLOGIES
USA
259.1
43
356
GRUNENTHAL
Germany
251.0
44
363
ONYX PHARMACEUTICALS
USA
246.5
45
379
BIOMARIN PHARMACEUTICAL
USA
229.1
46
389
BIOMERIEUX
France
218.6
47
406
TAISHO PHARMACEUTICAL
Japan
204.3
48
415
CHIESI FARMACEUTICI
Italy
198.0
49
424
NOVOZYMES
Denmark
193.7
50
459
ILLUMINA
USA
175.1