Oh, this is easy! Lucky*Star!
I really don't like the (afaik) most popular slice-of-life anime, Azumanga Daioh. Lucky*Star however is mainly about four girls, one of them very nerdy, and their conversations which circle around nothing in particular. I know it has a tendency to merely be classed as "moe bait" by some, but I found Azumanga much more annoying. In Lucky*Star I (as a v. nerdy girl) can occasionally identify myself with the characters. In Azumanga, everyone is such a "screwball" or otherwise weird, that I can mostly laugh at the characters. And I don't like that kind of humor.
People tend to compare Lucky*Star to Seinfeld, which I guess is true in that both shows contain a lot of talk about absolutely nothing. However, I found the humor of Seinfeld much more mean-spirited (also, less jokes about collecting doujinshi and buying multiple copies of the same thing to get All The Fannish Extramaterial, which, heh, is something I can and do recognize myself in) so in another sense, they're not that similar at all.
Anyways. Lucky*Star is my favorite slice-of-life anime. My fav s-o-l manga is Flower of Life by Fumi Yoshinaga, btw.
Click to view
It also has a very catchy intro!
Originally posted at
Dreamwidth.