(no subject)
SPEECH APHASIA
INTRO: Imagine being an individual who could not communicate or comprehend information that is nessicary to interact in everyday life. The frustration and difficulty that a person with this condition called aphasia deals with is all encompassing in their everyday life and forces them to react in a variety of different ways. Although aphasia is often not known about by the general public, there are more than twice the cases of aphasia then there are of individual's with Parkinson's Disease. Today, in the United States alone there are more than one million cases of aphasia and many more family member and friends that are affected by it.
Thesis: Because of the growing population of individuals living with aphasia, it is crucially important that the general public learns about the overall causes, types, and treatments of aphasia as well as new critical research on the forefront.
Unlike many other types of diseases, the term aphasia covers a wide variety of symptoms as well as many differing degrees and types of the condition. Aphasia is traditionally associated with the language centers of the brain which consist of Broca's Area, and Wernicke's Area, but with the current information being discovered through current research, areas such as the Insula, an area of cortex located deep within the cerebral hemisphere, are slowly being discovered and named. Broca's Area is usually located on the left hemisphere in the inferior frontal gyrus of the frontal lobe. This section of the brain, is currently thought to control the processing of language, speech production and comprehension. l, Wernicke's Area,As Nina Dronkers, PhD, a leading researcher in the field of brain mapping of aphasia, said at a language symposium during a American Psychological Association conference, "it’s much more interesting than that,' referring to Broca's and Wernicke's areas, "There are many, many other areas involved in language processing". Although there is still must to be learned and researched about in the field of neural pathways of speech and comprehension.
CURRENTLY PAPER FINISHED RESEARCH:http://stroke.ahajournals.org/cgi/content/abstract/30/7/1370
Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial
This study is currently recruiting patients.
Verified by Gabinete Berthier y Martínez March 2005
Sponsors and Collaborators: Gabinete Berthier y Martínez
H. Lundbeck A/S
Information provided by: Gabinete Berthier y Martínez
ClinicalTrials.gov Identifier: NCT00196703
Purpose
Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia can be treated with combination of speech-language therapy and drugs. Conventional speech-language therapy in chronic aphasic subjects is of little help and several drugs have been studied with limited success. Therefore other therapeutic strategies are warranted.
Recent data suggest that drugs (memantine) acting on the brain chemical glutamate may help the recovery of cognitive deficits, included language, in subjects with vascular dementia. The present study examines the safety profile and efficacy of memantine paired with intensive language therapy in subjects with stroke-related chronic aphasia (more than 1 yr. of evolution).
Condition Intervention Phase
Aphasia
Stroke
Drug: memantine
Procedure: constraint-induced language therapy
Phase IV
MedlinePlus related topics: Aphasia; Stroke
Genetics Home Reference related topics: Stroke
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Official Title: A 24-Week Pilot, Double-Blind, Randomized, Parallel, Placebo-Controlled Study of Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:Correlation With Cognitive Evoked Potentials During Recovery.
Further study details as provided by Gabinete Berthier y Martínez:
Primary Outcome Measures:
Language function (overall aphasia severity).
Communication
Secondary Outcome Measures:
Depression
Cognitive evaluation of language function
Changes in event-related potential
Research Projects looking for participants:This study is currently recruiting patients.
Verified by Department of Veterans Affairs September 2005
Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00223847
Purpose
The purpose of this study is to investigate the effects of intensive, constraint induced language therapy (CILT) for individuals with chronic aphasia compared with traditional aphasia therapy. The specific objectives of the proposed research are to determine the effects of therapy type (CILT vs. traditional) and dose density (intensive or distributed) on speech therapy outcome. In addition, we will investigate the functional and qualitative impact of these interventions on functional communication.
Dopaminergic Enhancement of Learning and Memory in Aphasia
This study is currently recruiting patients.
Verified by University Hospital Muenster April 2007
Sponsored by: University Hospital Muenster
Information provided by: University Hospital Muenster
ClinicalTrials.gov Identifier: NCT00102869
Purpose
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Condition Intervention Phase
Cerebrovascular Accident
Aphasia
Drug: levodopa
Phase IV
MedlinePlus related topics: Aphasia; Stroke
Genetics Home Reference related topics: Stroke
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Official Title: Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)
Further study details as provided by University Hospital Muenster:
Primary Outcome Measures:
Boost in naming performance (percent correct) through levodopa as compared to placebo
Brain activity pattern in successfully trained patients
Secondary Outcome Measures:
Stability of naming performance after one month and six months post treatment
http://www.ninds.nih.gov/disorders/aphasia/aphasia.htm#What_research_is_being_done
http://www.ninds.nih.gov/disorders/aphasia/aphasia.htm
Rose 2006
http://stroke.ahajournals.org/cgi/content/abstract/30/7/1370
Aphasia Community Groups
Stroke and aphasia support groups listed by state.
State Representatives Network
Volunteers who can answer questions about local resources for aphasia.
NAA Young People's Network
For younger people (up to age 30) with aphasia.
There are approximately twice as many people in the United States who have aphasia than there are individuals with Parkinson's Disease.
Yet the general public knows very little about aphasia. Of the estimated 400,000 strokes which occur each year, 80,000 result in aphasia. Approximately one million people, or one out of every 275 adults in the United States, have some type of aphasia. Ninety percent of those with aphasia who participated in this survey feel the public's awareness of this disability is minimal.
http://www.aphasia.org/naa_materials/impact_of_aphasia_on_patients_and_families.html
http://www.nidcd.nih.gov/health/statistics/vsl.asp
ORGANIZATIONS:Organizations
American Speech-Language-Hearing Association (ASHA)
10801 Rockville Pike
Rockville, MD 20852-3279
actioncenter@asha.org
http://www.asha.org
Tel: 800-638-8255
Fax: 301-571-0457
National Aphasia Association
7 Dey Street
Suite 600
New York, NY 10007
naa@aphasia.org
http://www.aphasia.org
Tel: 212-267-2814 800-922-4NAA (4622)
Fax: 212-267-2812
Aphasia Hope Foundation
2436 West 137th Place
Leawood, KS 66224
judistradinger@aphasiahope.org
http://www.aphasiahope.org
Tel: 913-402-8306 866-449-5804
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institutes of Health, DHHS
31 Center Drive, MSC 2320
Bethesda, MD 20892-2320
nidcdinfo@nidcd.nih.gov
http://www.nidcd.nih.gov
Tel: 301-496-7243/800-241-1044 800-241-1055 (TTD/TTY)
INTRO: Imagine being an individual who could not communicate or comprehend information that is nessicary to interact in everyday life. The frustration and difficulty that a person with this condition called aphasia deals with is all encompassing in their everyday life and forces them to react in a variety of different ways. Although aphasia is often not known about by the general public, there are more than twice the cases of aphasia then there are of individual's with Parkinson's Disease. Today, in the United States alone there are more than one million cases of aphasia and many more family member and friends that are affected by it.
Thesis: Because of the growing population of individuals living with aphasia, it is crucially important that the general public learns about the overall causes, types, and treatments of aphasia as well as new critical research on the forefront.
Unlike many other types of diseases, the term aphasia covers a wide variety of symptoms as well as many differing degrees and types of the condition. Aphasia is traditionally associated with the language centers of the brain which consist of Broca's Area, and Wernicke's Area, but with the current information being discovered through current research, areas such as the Insula, an area of cortex located deep within the cerebral hemisphere, are slowly being discovered and named. Broca's Area is usually located on the left hemisphere in the inferior frontal gyrus of the frontal lobe. This section of the brain, is currently thought to control the processing of language, speech production and comprehension. l, Wernicke's Area,As Nina Dronkers, PhD, a leading researcher in the field of brain mapping of aphasia, said at a language symposium during a American Psychological Association conference, "it’s much more interesting than that,' referring to Broca's and Wernicke's areas, "There are many, many other areas involved in language processing". Although there is still must to be learned and researched about in the field of neural pathways of speech and comprehension.
CURRENTLY PAPER FINISHED RESEARCH:http://stroke.ahajournals.org/cgi/content/abstract/30/7/1370
Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial
This study is currently recruiting patients.
Verified by Gabinete Berthier y Martínez March 2005
Sponsors and Collaborators: Gabinete Berthier y Martínez
H. Lundbeck A/S
Information provided by: Gabinete Berthier y Martínez
ClinicalTrials.gov Identifier: NCT00196703
Purpose
Aphasia, the loss or impairment of language caused by brain damage, is one of the most devastating cognitive impairments of stroke. Aphasia can be treated with combination of speech-language therapy and drugs. Conventional speech-language therapy in chronic aphasic subjects is of little help and several drugs have been studied with limited success. Therefore other therapeutic strategies are warranted.
Recent data suggest that drugs (memantine) acting on the brain chemical glutamate may help the recovery of cognitive deficits, included language, in subjects with vascular dementia. The present study examines the safety profile and efficacy of memantine paired with intensive language therapy in subjects with stroke-related chronic aphasia (more than 1 yr. of evolution).
Condition Intervention Phase
Aphasia
Stroke
Drug: memantine
Procedure: constraint-induced language therapy
Phase IV
MedlinePlus related topics: Aphasia; Stroke
Genetics Home Reference related topics: Stroke
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Official Title: A 24-Week Pilot, Double-Blind, Randomized, Parallel, Placebo-Controlled Study of Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:Correlation With Cognitive Evoked Potentials During Recovery.
Further study details as provided by Gabinete Berthier y Martínez:
Primary Outcome Measures:
Language function (overall aphasia severity).
Communication
Secondary Outcome Measures:
Depression
Cognitive evaluation of language function
Changes in event-related potential
Research Projects looking for participants:This study is currently recruiting patients.
Verified by Department of Veterans Affairs September 2005
Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00223847
Purpose
The purpose of this study is to investigate the effects of intensive, constraint induced language therapy (CILT) for individuals with chronic aphasia compared with traditional aphasia therapy. The specific objectives of the proposed research are to determine the effects of therapy type (CILT vs. traditional) and dose density (intensive or distributed) on speech therapy outcome. In addition, we will investigate the functional and qualitative impact of these interventions on functional communication.
Dopaminergic Enhancement of Learning and Memory in Aphasia
This study is currently recruiting patients.
Verified by University Hospital Muenster April 2007
Sponsored by: University Hospital Muenster
Information provided by: University Hospital Muenster
ClinicalTrials.gov Identifier: NCT00102869
Purpose
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Condition Intervention Phase
Cerebrovascular Accident
Aphasia
Drug: levodopa
Phase IV
MedlinePlus related topics: Aphasia; Stroke
Genetics Home Reference related topics: Stroke
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Official Title: Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)
Further study details as provided by University Hospital Muenster:
Primary Outcome Measures:
Boost in naming performance (percent correct) through levodopa as compared to placebo
Brain activity pattern in successfully trained patients
Secondary Outcome Measures:
Stability of naming performance after one month and six months post treatment
http://www.ninds.nih.gov/disorders/aphasia/aphasia.htm#What_research_is_being_done
http://www.ninds.nih.gov/disorders/aphasia/aphasia.htm
Rose 2006
http://stroke.ahajournals.org/cgi/content/abstract/30/7/1370
Aphasia Community Groups
Stroke and aphasia support groups listed by state.
State Representatives Network
Volunteers who can answer questions about local resources for aphasia.
NAA Young People's Network
For younger people (up to age 30) with aphasia.
There are approximately twice as many people in the United States who have aphasia than there are individuals with Parkinson's Disease.
Yet the general public knows very little about aphasia. Of the estimated 400,000 strokes which occur each year, 80,000 result in aphasia. Approximately one million people, or one out of every 275 adults in the United States, have some type of aphasia. Ninety percent of those with aphasia who participated in this survey feel the public's awareness of this disability is minimal.
http://www.aphasia.org/naa_materials/impact_of_aphasia_on_patients_and_families.html
http://www.nidcd.nih.gov/health/statistics/vsl.asp
ORGANIZATIONS:Organizations
American Speech-Language-Hearing Association (ASHA)
10801 Rockville Pike
Rockville, MD 20852-3279
actioncenter@asha.org
http://www.asha.org
Tel: 800-638-8255
Fax: 301-571-0457
National Aphasia Association
7 Dey Street
Suite 600
New York, NY 10007
naa@aphasia.org
http://www.aphasia.org
Tel: 212-267-2814 800-922-4NAA (4622)
Fax: 212-267-2812
Aphasia Hope Foundation
2436 West 137th Place
Leawood, KS 66224
judistradinger@aphasiahope.org
http://www.aphasiahope.org
Tel: 913-402-8306 866-449-5804
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institutes of Health, DHHS
31 Center Drive, MSC 2320
Bethesda, MD 20892-2320
nidcdinfo@nidcd.nih.gov
http://www.nidcd.nih.gov
Tel: 301-496-7243/800-241-1044 800-241-1055 (TTD/TTY)