After all the hullabaloo that occurred with the IMDB "revelation" of Jenna Louise Coleman's character's name (go look for yourself), I tried to find Moffat interviews that had been mentioned in the comments of
kilodalton's post on the same subject.
The Daily Beast, Moffat interview, 22 Aug 11 How has the dynamic changed within the TARDIS to have a married couple along for the ride?
In very fun and interesting ways…The big thing with the Doctor is that he thinks he’s…intruded for too long. Each time he tries to extricate himself, there’s another complexity that means that he can’t. Suddenly, she’s married. Her husband-to-be is dead, then he’s suddenly back again, he’s on their honeymoon, he’s dating their daughter. It’s complex and that’s what he’s always thinking: when is he going to get his exit? He has an exit strategy for all of these relationships, including Rose, whom he loved so much, because he knows he can’t hang around, he’s going to cause too much damage. In one of the upcoming episodes, he sits in this room and says, “I can’t keep doing this to them.” It’s too much, it’s too deadly.
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Hitflix interview with Moffat, 24 Aug 11 This may be something that's addressed in the remaining six episodes, and if so you don't need to answer, but Amy has been attracted to the Doctor, the Doctor has some sort of relationship with what turns out to be Amy's daughter - what is the meaning of that, from a Freudian perspective, or whatever?
(Laughs) Well, he didn't know! And first of all, he does comprehensively reject Amy's advances. He absolutely says "No." And that has nothing to do with whatever relationship he has with River. It has to do that for the Doctor, Amy will always be 7. And that's just appalling to him. Not that he isn't aware that she's pretty. And it's fan-generated nonsense to say that the Doctor doesn't like pretty women. The entire run of the show tells you the true story about that. But he absolutely says no. I'm not sure, if Rose had flung herself at him in that way, that he wouldn't have just gone with it. Probably would if River did.
So I'm not sure there's that kind of complexity. There's a temporal problem there. River seems to him like an older person, someone more like him, and Amy seems like a child, and oddly enough Amy is the mother of River.
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Anyway, that's what I've found so far. If anyone has anything else, please do point me in the correct direction.